Serotonin
Kod:12016|CPT:84260|LOINC:27057-9
| Kabi | Serotonin, qon zardobi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Suyuq xromatografiya va tandem mass-spektrometriya (LC-MS/MS)
- Yuqori samarali suyuq xromatografiya (HPLC)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Record the patient’s sex on the test request form.
- Infants younger than 1 year: fast for 30–40 minutes before collection; water is allowed.
- Children 1–5 years: fast for 2–3 hours before collection; water is allowed.
- Avoid avocado, bananas, eggplant, pineapple, plums, tomatoes, and walnuts for 72 hours prior to collection.
- Fast for 12 hours before collection; consume only plain, noncarbonated water.
- If clinically appropriate and approved by the physician, stop sympathomimetic agents 14 days before collection.
- If clinically appropriate and approved by the physician, avoid all medications for 24 hours before collection.
- Avoid physical exertion and emotional stress for 24 hours before collection.
- Do not smoke during the 2 hours preceding collection.
Qanday foydalanish
Serotonin, qon zardobi (5-HT; 5-gidroksitriptamin) gastroenteropankreatik neyroendokrin o‘smalardan kelib chiqadigan gumon qilingan karsinoid sindromni baholashda qo‘llaniladi. Natija odatda siydikdagi 5-gidroksiindol-sirka kislotasi (5-HIAA) va/yoki zardobdagi xromogranin A bilan integratsiyalangan holda talqin qilinadi, bu diagnostik bahoni yaxshilaydi. Ushbu test, shuningdek, serotonin ishlab chiqaruvchi o‘smalar jarrohlik yo‘li bilan rezektsiya qilingandan so‘ng bemorlarni kuzatishda biokimyoviy qaytalanish yoki davomiylikni kuzatishga yordam berish uchun qo‘llanishi mumkin.
Cheklovlar
Serotonin triptofandan sintezlanadi va asosan gastrointestinal tizimning entero-xromaffin hujayralarida saqlanadi; ular organizmning asosiy zaxirasini tashkil etadi. Qo‘shimcha zaxiralar trombotsitlar, mast hujayralar, markaziy asab tizimi va boshqa endokrin to‘qimalarda mavjud. Fiziologik ta’sirlari og‘riqni qabul qilish va gipofiz funksiyasini modulyatsiya qilish, tomir tonusi va koagulyatsiyani tartibga solish hamda ovqat hazm yo‘li motorikasi va sekretsiyasini boshqarishni o‘z ichiga oladi. O‘rta ichakning neyroendokrin (karsinoid) o‘smalari ko‘pincha serotonin ishlab chiqaradi va qo‘shimcha ravishda substansiya P ni koaekspressiya qilishi mumkin. Jigar metabolizmi haddan tashqari yuklanganda karsinoid sindrom deb ataladigan klinik majmua paydo bo‘lishi mumkin; u qizarish (flushing), sekretor diareya, bronxospazm va yurakning o‘ng bo‘limlari klapan kasalligi bilan tavsiflanadi. Gastroenteropankreatik neyroendokrin o‘smalarning barchasi ham aylanmadagi serotoninni oshirmaydi; ko‘plab hollarda siydikdagi 5-gidroksiindol-sirka kislotasi (5-HIAA) va zardob xromogranin A yuqoriroq analitik sezuvchanlikni ta’minlaydi. Aromatik aminokislota dekarboksilaza yetishmovchiligi bo‘lgan kam uchraydigan o‘smalarda 5-gidroksitriptofanni serotoninga aylanish cheklangan bo‘ladi, bu esa zardob serotonini oshishini yanada kamaytiradi.
| O'lchov birligi | ng/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Workup for suspected carcinoid syndrome due to gastroenteropancreatic neuroendocrine tumors, particularly when flushing, secretory diarrhea, bronchospasm, or right-sided valvular heart disease is reported, Assessment in the setting of possible intestinal obstruction, Unexplained, unintentional weight loss, Postoperative follow-up after removal of carcinoid (serotonin-secreting) tumors, Evaluation of symptoms consistent with dumping syndrome, Assessment in patients with irritable bowel syndrome–like complaints, Evaluation of suspected malabsorption syndrome, Testing in individuals with hereditary predisposition to multiple endocrine neoplasia syndromes, Evaluation of pellagra-like manifestations attributable to niacin deficiency from tryptophan shunting in carcinoid disease |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- lithium
- methyldopa
- monoamine oxidase inhibitors
- morphine
- reserpine
Pasaygan daraja
- selective serotonin reuptake inhibitors
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Kocha W, Maroun J, Kennecke H, et al. Consensus recommendations for the diagnosis and management of well-differentiated gastroentererohepatic neuroendocrine tumours: a revised statement from a Canadian National Expert Group. Curr Oncol. 2010;17(3):49-64. PMID: 20567626.
Meijer W, Kema I, Volmer M, Willemse PH, de Vries EG. Discriminating capacity of indole markers in the diagnosis of carcinoid tumors. Clin Chem. 2000;46(10):1588-1596. PMID: 11017936.