Kardiolipinga qarshi antitanachalar, IgG
Kod:17044
| Kabi | Kardiolipin IgG antitanachasi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment bilan bog'langan immunosorbent analiz (ELISA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Kardiolipinga qarshi antitanachalar, IgG (IgG anti‑kardiolipin; aCL IgG) antifosfolipid sindromi diagnostikasiga yordam beradi va trombofiliyaning differensial diagnostikasiga hissa qo‘shadi. U tushunarsiz arterial yoki venoz tromboembolizmni, takroriy homilani yo‘qotish va bog‘liq akusherlik asoratlarini baholash, shuningdek sistemali qizil yugurukda ikkilamchi antifosfolipid sindromiga shubha bo‘lganda tekshirish uchun buyuriladi. Klinik kontekst va boshqa antifosfolipid testlari, masalan, lupus antikoagulyanti va anti–beta-2 glikoprotein I natijalari bilan birga qo‘llanganda, ushbu test qaytalanuvchi tromboz yoki kelajakdagi homiladorlik asoratlari xavfini baholashda ma’lumot beradi.
Cheklovlar
IgG anti‑kardiolipin antitanachalari oqsil‑fosfolipid komplekslarini tan oladigan va endotel faollashuvi, trombotsitlar faollashuvi hamda ivish yo‘llarining buzilishi orqali trombozni rag‘batlantirishi mumkin bo‘lgan geterogen antifosfolipid antitanachalar oilasining bir qismidir. Antifosfolipid sindromi arterial va/yoki venoz tromboz hamda homiladorlik morbidligi bilan namoyon bo‘ladi va immunologik jihatdan kamida ikki marta, 12 yoki undan ortiq haftalik interval bilan o‘tkazilgan tekshiruvlarda anti‑kardiolipin IgG va/yoki IgM, anti–beta-2 glikoprotein I yoki lupus antikoagulyantiga doimiy ijobiylik bilan belgilanadi. Trombotik hodisalar sababsiz ham, shuningdek jarrohlik, shikastlanish, homiladorlik yoki estrogen ta’siri kabi triggerlar bilan ham yuz berishi mumkin; ular venoz yoki arterial qon aylanishini qamrab olishi mumkin. Akusherlik ko‘rinishlariga takroriy erta homila tushishi, homila o‘limi, preeklampsiya, platsentar yetishmovchilik va boshqa sabablar bilan izohlanmaydigan muddatidan oldin tug‘ruq kiradi. Yuqori anti‑kardiolipin IgG titrlari (masalan, >40 GPL birliklari) ishemik insult va takroriy homilani yo‘qotish xavfining ortishi bilan korrelyatsiya qiladi, va titrning ortishi, odatda, kattaroq trombotik xavfga mos keladi.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Evaluation for suspected antiphospholipid syndrome, Unexplained venous or arterial thromboembolism, Young patients with ischemic stroke, myocardial infarction, pulmonary embolism, or pulmonary hypertension in the absence of traditional risk factors, Recurrent miscarriage or other obstetric complications associated with antiphospholipid syndrome, Systemic lupus erythematosus with concern for secondary antiphospholipid syndrome |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- hepatitis b
- hiv infection
- lyme disease
- malignancy
- syphilis
- tuberculosis
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.5 mL) |
| Saqlash tayyorlik | Sovutilgan, Muzlatilgan |
References
Hematology: Basic Principles and Practice. Seventh Edition. Hoffman, Ronald, MD; Benz, Edward J., MD; Silberstein, Leslie E., MD; Heslop, Helen E., MD, DSc (Hon); Weitz, Jeffrey I., MD; Anastasi, John, MD; Salama, Mohamed E., MD; Abutalib, Syed Ali, MD. Copyright © 2018 by Elsevier, Inc.
Antiphospholipid Syndrome : Pathogenesis, Clinical Presentation, Diagnosis, and Patient Management. Jacob H. Rand MD, FACP and Lucia R. Wolgast MD. Consultative Hemostasis and Thrombosis, 20, 324-341
Caplan's Stroke, Chapter 4, 87-145.
Review Clinical laboratory testing for the antiphospholipid syndrome Silvia S. Pierangelia,b, T, E. Nigel Harrisc.
Association between IgM anticardiolipin antibodies and deep venous thrombosis in patients without systemic lupus erythematosus.Oger E, Lernyer C, Dueymes M, Le Moigne E, Bressolette L, Escoffre M, Youinou P, Mottier D – Lupus – January 1, 1997; 6 (5); 455-61.
A protocol for determination of anticardiolipin antibodies by ELISA Silvia S Pierangeli1, Eon Nigel Harris. Published online 17 April 2008; doi:10.1038/nprot.2008.48.