Sitomegalovirus (CMV) ga qarshi IgG antitanalari
Kod:18024
| Kabi | Sitomegalovirus (CMV) ga qarshi IgG antitanasi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Elektrokimyoluminessent immunoanaliz (ECLIA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Sitomegalovirus (CMV) Antibody, IgG (Anti-CMV IgG, CMV IgG antitanasi) avvalgi CMV infeksiyasini aniqlash va immun holatni baholash uchun qo‘llanadi. CMV ga xos klinik holatlarda serologik holat, ayniqsa Epsteyn–Barr virusi bo‘yicha tekshiruvlar manfiy bo‘lsa, kasallikni CMV bilan bog‘lashni qo‘llab-quvvatlaydi. Akusherlik amaliyotida CMV IgG — yakka holda yoki juft zardob namunalari va/yoki IgG avidligi bilan birga — tug‘ma CMV xavfini tabaqalashtirishga yordam beradi. Immunokomprometlangan bemorlarda CMV serologiyasi gumon qilingan CMV bilan bog‘liq kasallikni diagnostik baholashga hissa qo‘shadi.
Cheklovlar
Sitomegalovirus — umrbod latentlikni o‘rnatadigan va reaktivatsiyalanishi mumkin bo‘lgan odam gerpes virusi. Yuqish tupurik, siydik, sperma va qon orqali, shuningdek vertikal yo‘llar bilan — bachadon ichi (in utero), tug‘ruq vaqtida yoki ko‘krak suti orqali sodir bo‘ladi. Immunokompetent shaxslarda birlamchi infeksiya ko‘pincha simptomsiz kechadi yoki mononukleozga o‘xshash sindrom bilan namoyon bo‘ladi. Homiladorlikda onadagi birlamchi infeksiya tug‘ma CMV xavfi bilan bog‘liq; tug‘ma zararlangan chaqaloqlarning bir qismi mikrotsifaliya, intrakranial kalsifikatsiyalar, toshma, gepatosplenomegaliya va sensorinevral eshitish yo‘qotilishi kabi belgilar bilan kechuvchi simptomatik kasallikni rivojlantiradi. Birlamchi infeksiyadan so‘ng bir necha hafta ichida IgG antitanalar hosil bo‘ladi va yillar davomida saqlanib qoladi. IgG avidligi vaqt o‘tishi bilan ortadi va yaqinda o‘tkazilgan birlamchi infeksiyani (past avidlik) o‘tmishdagi infeksiya yoki reaktivatsiyadan (yuqori avidlik) farqlashga yordam beradi. Onalik IgG platsenta orqali o‘tganligi sababli, yangi tug‘ilgan chaqaloqda IgG serologiyasi tug‘ma infeksiyani tasdiqlamaydi.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Preconception or prenatal assessment of CMV serostatus and congenital CMV risk, or when fetal ultrasound findings raise concern for intrauterine infection, Evaluation of suspected CMV disease in immunocompromised individuals, Mononucleosis-like presentation with negative Epstein–Barr virus testing |
Namunangiz talablari
| Namunangiz | Tezkor PCR namunasi |
|---|---|
| Container | Tezkor test kartriji / tampon |
References
Adler S. P. Screening for cytomegalovirus during Pregnancy. Infect Dis Obstet Gynecol. 2011:1–9.
Goldman's Cecil Medicine. 24th ed. Goldman L, Schafer A.I., eds. Saunders Elsevier; 2011.
Lazzarotto T. et al. Why is cytomegalovirus the most frequent cause of congenital infection? Expert Rev Anti Infect Ther. 2011; 9(10): 841–843.
Belshe RB, ed. Textbook of Human Virology. Littleton, Mass: PSG Publishing Co;1984.
Drew WL. Controversies in viral diagnosis. Rev Infect Dis. 1986 Sep-Oct; 8(5):814-824. PubMed 3024292
Korones SB. Uncommon virus infections of the mother, fetus, and newborn: Influenza, mumps, and measles. Clin Perinatol. 1988 Jun; 15(2):259-272. PubMed 3288423
Lennette DA. Preparation of specimens for virological examination. In: Balows A, Hausler WJ, et al, eds. Manual of Clinical Microbiology. 5th ed. Washington, DC: ASM Press;1991:818-821.
Pfaller MA, Caliendo AM, Versalovic J. Detection of herpes simplex virus in CSF by PCR. In: Isenberg HD, ed. Clinical Microbiology Procedures Handbook. 2nd ed. Washington, DC: ASM Press: 2004:12.2.3.51-12.2.3.61.