Eozinofil kationik oqsil (ECP)
Kod:20001
| Kabi | Eozinofil kationik oqsil |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kimyoluminessent immunoanaliz (CLIA)
- Fluoressent ferment immunoanalizi (FEIA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Infants younger than 1 year: avoid feeding for 30–40 minutes before collection
- Children 1–5 years: do not eat for 2–3 hours before collection
- Adults: fast for 8 hours; water is allowed
- Avoid vigorous physical activity and emotional stress for 30 minutes prior to collection
- Do not smoke during the 3 hours before collection
Qanday foydalanish
Eozinofil kationik oqsil (ECP) testi bronxial astma, atopik dermatit, allergik rinit, oziq-ovqat allergiyasi va ular bilan bog'liq allergik kasalliklarda tashxis qo'yishga yordam berish, og'irlik darajasini baholash va monitoring uchun qo'llaniladi. Gelmint infeksiyasi gumon qilinganda baholashni qo'llab-quvvatlashi mumkin. ECP ni ketma-ket o'lchash yallig'lanishga qarshi davolashga javobni baholash va astmada inhalyatsion kortikosteroid dozasini titrlashni yo'naltirish uchun qo'llanilishi mumkin.
Cheklovlar
Eozinofil kationik oqsil eozinofil granulalari tarkibidagi ribonukleaza bo'lib, IgE vositachiligidagi yoki boshqa shakldagi faollashuvdan so'ng ajraladi. ECP epiteliya hujayralari, mast hujayralar, silliq mushak hujayralari va fibroblastlar uchun sitotoksik bo'lib, immunitetni Th2-ustun javobni qo'llab-quvvatlaydigan tarzda modulyatsiya qiladi. Eozinofillar nafas va me'da-ichak yo'lining shilliq qavati to'qimalarida hamda ko'plab parenximatoz organlarda rezident bo'lgani sababli, ECP ajralishi keng klinik namoyonlar bilan bog'liq. Qon zardobidagi ECP allergen ta'siridan so'ng oshadi va eozinofil yuklamasi hamda astmada nafas yo'llari shilliq qavatining yallig'lanishi bilan korrelyatsiya qiladi, biroq bronxial giperreaktivlik bilan korrelyatsiya qilmaydi. Yuqoriroq konsentratsiyalar invaziv gelmint infeksiyalarida va atopik dermatit xurujlari paytida kuzatiladi; eng yuqori qiymatlar gipereozinofilik sindromda qayd etiladi. ECP ning ko'tarilishi allergiyaga xos emas va bakterial sinusitda, ayrim buyrak neoplaziyalarida hamda respirator sinsitial virus infeksiyasida ham kuzatilishi mumkin. Eozinofiliya va sistemik alomatlar bilan kechuvchi dori reaksiyasi (DRESS) ECP ning sezilarli oshishi bilan bog'liq. Talqin klinik topilmalar va boshqa laborator ma'lumotlar, zarurat bo'lganda allergen testlari bilan birgalikda amalga oshirilishi kerak.
| O'lchov birligi | mcg/L | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Asthma with suspected eosinophilic airway inflammation; estimation of disease severity, Evaluation of allergic rhinitis, atopic dermatitis, or possible food allergy, Workup of suspected helminthic infection, Monitoring response to anti-inflammatory therapy in eosinophilic or allergic disorders |
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Saqlash tayyorlik | Sovutilgan |
References
Avdeeva SN, Brazhnikova NA. Eosinophilic cationic protein as a marker of allergic inflammation in bronchial asthma in children. Pediatrics. 2015;94(6):63–68.
Belevsky AS, Khaitov MR. Eosinophilic cationic protein in the diagnosis and monitoring of bronchial asthma. Pulmonology. 2009;(3):109–114.
Vishnyakova LA, Baltaitis IV, Kungurov NV. Clinical significance of serum eosinophilic cationic protein in patients with atopic dermatitis. Russian Journal of Skin and Venereal Diseases. 2012;(5):20–23.
Volokhova EA, Novik GA. Eosinophilic cationic protein as a marker of airway allergic inflammation. Practical Medicine. 2010;(45):59–63.