Lupus antikoagulyanti
Kod:3013
| Kabi | DRVVT skriningi DRVVT tasdiqlash DRVVT nisbati Interpretatsiya |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Suyultirilgan Rassel ilon zahari testi (dRVVT)
- Volchanka antikoagulyantiga qisman tromboplastin vaqti (PTT-LA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- For infants younger than 1 year, withhold feeds for 30–40 minutes before collection.
- Do not eat for 2–3 hours before the blood draw; water is allowed.
- In coordination with the treating clinician, hold heparin and related agents for 5 days before collection when clinically appropriate.
- Avoid vigorous physical activity and minimize emotional stress for 30 minutes prior to collection.
- Do not smoke during the 30 minutes before specimen collection.
- When feasible, obtain the specimen before starting anticoagulant therapy.
Qanday foydalanish
Lupus antikoagulyanti testi (shuningdek lupus ingibitori bo‘yicha test sifatida ham ma’lum) sababi tushuntirilmagan tromboz va takrorlanuvchi homila yo‘qotilishini baholashda qo‘llanadi. U uzaygan faollashtirilgan qisman tromboplastin vaqti (aPTT)ni tekshiruvda LA ni ma’lum koagulyatsiya omili ingibitoridan farqlashga yordam beradi va boshlang‘ich skrining natijasidan so‘ng LA ni tasdiqlash uchun qo‘llanishi mumkin. LA baholash LAga sezgir aPTT (PTT-LA) va DRVVTga asoslangan yondashuvlarni o‘z ichiga olishi mumkin. Antifosfolipid sindromining diagnostik bahosida LA testi antikardiolipin va anti-beta-2 glikoprotein I antitana tahlillari bilan birgalikda talqin qilinadi.
Cheklovlar
Lupus antikoagulyantlari fosfolipidlarga va/yoki fosfolipid bilan bog‘liq oqsillarga qarshi avtoantitanalar bo‘lib, in vitro fosfolipidga bog‘liq koagulyatsiya tahlillarini cho‘zadi, biroq in vivo paradoksal tarzda protrombotik holat bilan bog‘liq. Dastlab tizimli qizil volchanka (systemic lupus erythematosus)da tasvirlangan, ular boshqa autoimmun buzilishlar, infeksiyalar, yomon sifatli o‘sma va ayrim dori ta’sirlarida ham uchraydi. LA venoz hamda arterial tromboz xavfini oshiradi va homiladorlik morbidligi, shu jumladan homila yo‘qotilishi bilan bog‘liq, ayniqsa ikkinchi va uchinchi trimestrlarda. LA ni yagona biror tahlil aniqlab bermaydi. Aniqlash ketma-ket fosfolipidga bog‘liq skrining sinovlariga (masalan, DRVVT yoki LAga sezgir aPTT) tayanadi; undan so‘ng aralashtirish sinovlari va ortiqcha fosfolipid bilan tuzatilish namoyon bo‘ladigan tasdiqlovchi protseduralar qo‘llanib, fosfolipidga bog‘liqlik tasdiqlanadi. LA antifosfolipid sindromi uchun uchta laboratoriya mezonidan biridir; qolganlari antikardiolipin va anti-beta-2 glikoprotein I antitanalaridir.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Workup of thrombotic events in either the venous or arterial circulation, Assessment of a persistently prolonged activated partial thromboplastin time (aPTT) to differentiate a lupus anticoagulant from a single‑factor inhibitor, Confirmatory evaluation in individuals already positive for anticardiolipin or other antiphospholipid antibodies |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- argatroban
- danaparoid
- heparin
- hirudin
Namunangiz talablari
| Namunangiz | Plazma |
|---|---|
| Container | Och ko'k qopqoqli probirka (3,2% natriy sitrat) |
| Saqlash tayyorlik | Sovutilgan, Muzlatilgan |