C‑peptid, 24 soatlik siydik
Kod:7011
| Kabi | C‑peptid |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kimyoluminessent immunoanaliz (CLIA)
- Elektrokimyoluminessent immunoanaliz (ECLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not consume alcohol during the 24 hours before starting the urine collection.
- Only in consultation with the treating clinician, stop diuretics 48 hours before beginning the collection.
- Avoid strenuous exercise and minimize emotional stress throughout the 24-hour collection period.
Qanday foydalanish
C‑peptid, 24 soatlik siydik (siydikdagi C‑peptid; UCP) endogen insulin sekretsiyasini baholaydi va diabetni tasniflash hamda boshqarishga oid qarorlarni qo‘llab-quvvatlaydi. Bolalarda bu tahlil 1‑tur qandli diabetni MODYdan farqlashga yordam beradi; kattalarda esa 2‑tur qandli diabetni LADAdan ajratishga ko‘maklashadi. Shuningdek, 1‑tur qandli diabetning qisman remissiya (honeymoon) fazasida insulin dozasini titrlashga va 2‑tur qandli diabetda insulin terapiyasiga o‘tish ko‘rilayotganda mutlaq insulin yetishmovchiligini aniqlashga yordam beradi. Qaytalanuvchi gipoglikemiyani tekshirishda siydikdagi C‑peptid endogen giperinsulinizmni (masalan, insulinoma) ekzogen insulin yuborilishidan farqlashga yordam beradi.
Cheklovlar
C‑peptid oshqozon osti bezi beta‑hujayralaridan insulin bilan ekvimolyar miqdorda ajraladi va endogen insulin ishlab chiqarilishining to‘g‘ridan‑to‘g‘ri ko‘rsatkichi sifatida xizmat qiladi. Odatda qonda o‘lchansa‑da, vaqtli 24 soatlik siydik yig‘imida C‑peptidni aniqlash zardobdagi konsentratsiyalar bilan mos keladi va takroriy tekshiruvlar hamda pediatriyada qo‘llashni yengillashtiruvchi noinvaziv yondashuvni taqdim etadi. Bolalarda siydikdagi C‑peptid avtoimmun 1‑tur qandli diabetni—beta‑hujayralar destruksiyasi bilan kechib, mutlaq insulin yetishmovchiligiga olib keladigan holat—MODYdan, ya’ni odatda insulin terapiyasini talab qilmaydigan insulinning sekretsiyasidagi monogen nuqsondan, ajratishga yordam beradi. Kattalarda u 2‑tur qandli diabetni kech boshlanuvchi, avtoimmun shakl bo‘lgan LADAdan farqlashga ko‘maklashadi; bu shakl odatda insulin bog‘liqligiga o‘tadi. Seriyali o‘lchovlar 2‑tur qandli diabetda beta‑hujayra funksiyasining pasayishini hujjatlashtirishi va insulin terapiyasini o‘z vaqtida boshlashni qo‘llab‑quvvatlashi mumkin. Qaytalanuvchi gipoglikemiyasi bo‘lgan bemorlarda siydikdagi C‑peptid endogen giperinsulinizmni (masalan, insulinoma) ekzogen insulin qo‘llanishidan farqlashga yordam beradi; ikkinchi holatda endogen insulin sekretsiyasi susayadi va C‑peptid past bo‘ladi.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Clinical presentation suggesting type 1 diabetes mellitus, such as polyuria, polydipsia, and polyphagia, Features concerning for type 2 diabetes mellitus with progressive visual loss, distal symmetric sensory neuropathy, and chronic lower-limb ulcers, Distinguishing type 1 diabetes mellitus from MODY in pediatric patients, Differentiating type 2 diabetes mellitus from LADA in adults, Guidance for insulin titration during the partial remission (honeymoon) phase of type 1 diabetes mellitus, Determination of absolute insulin deficiency in type 2 diabetes mellitus to support initiation of insulin therapy, Assessment of recurrent hypoglycemia with adrenergic and neuroglycopenic manifestations, including syncope |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- cirrhosis
- chronic hepatitis
Pasaygan daraja
- chronic kidney disease
Namunangiz talablari
| Namunangiz | Urina |
|---|---|
| Container | Sutkalik siydik yig'ish idishi |
References
Bonser AM, Garcia-Webb P. C-peptide measurement: methods and clinical utility. Crit Rev Clin Lab Sci. 1984;19(4):297-352.
Aurbach-Klipper J, Sharph-Dor R, Heding LG, Karp M, Laron Z. Residual B cell function in diabetic hildren as determined by urinary C-peptide. Diabetologia. 1983;24:88–90.
Chernecky CC, Berger BJ. Laboratory Tests and Diagnostic Procedures; 5th ed. Saunders Elsevier; 2008.
Koskinen P, Viikari J, Irjala K, Kaihola HL, Seppälä P. Plasma and urinary C-peptide in the classification of adult diabetics. Scand J Clin Lab Invest. 1986;46:655–663.
Besser R. Outpatient Test Discriminates MODY From Type 1 Diabetes. European Association for the Study of Diabetes (EASD) 47th Annual Meeting; September 12–16, 2011; Lisbon, Portugal.