Non-HDL xolesterin profili
Kod:8018|CPT:82465, 83718|LOINC:2093-3, 2085-9, 43396-1
| Kabi | Umumiy xolesterin HDL xolesterin Non-HDL xolesterin Izoh: |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kolorimetrik / fotometrik usul
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Record the patient's age and sex on the test requisition.
- Infants younger than 1 year: withhold feeding for 30–40 minutes before the blood draw.
- Children 1–5 years: maintain a 2–3 hour fast before collection.
- Adolescents and adults: fast for 12 hours; water is permitted.
- Avoid vigorous physical activity and emotional stress for 30 minutes prior to phlebotomy.
- Do not smoke during the 30 minutes before specimen collection.
Qanday foydalanish
Non-HDL xolesterin profili yurak-qon tomir xavfini tabaqalashtirish va dislipidemiya boshqaruvida davolash maqsadi sifatida qo‘llanadi. U ayniqsa gipertrigliseridemiya, metabolik sindrom yoki diabet sharoitida foydalidir; bu holatlarda hisoblangan past zichlikdagi lipoprotein xolesterini (LDL-C) kamroq ishonchli bo‘lishi mumkin. Non–HDL-C umumiy xolesterindan HDL-C ayirmasiga teng bo‘lgani sababli, u aterogen zarrachalar (VLDL, IDL, LDL va lipoprotein[a]) tashiydigan xolesterinni ifodalaydi. Non–HDL-C bo‘yicha terapevtik chegaralar odatda mos LDL-C maqsadlaridan 30 mg/dL yuqoriroq belgilanadi va ushbu ko‘rsatkich parhez aralashuvlari hamda lipidlarni pasaytiruvchi farmakoterapiya samaradorligini baholash uchun kuzatiladi.
Cheklovlar
Xolesterin hujayra membranasi butunligini saqlash, steroid gormonlar ishlab chiqarilishi va o‘t kislotalari hosil bo‘lishi uchun zarur bo‘lgan asosiy lipid hisoblanadi. Suvda erimaganligi sababli, u plazmada lipidlar va apolipoproteinlardan tashkil topgan lipoprotein zarrachalari tarkibida aylanadi. Lipoproteinlarning asosiy sinflari juda past zichlikdagi lipoproteinlar (VLDL), past zichlikdagi lipoproteinlar (LDL) va yuqori zichlikdagi lipoproteinlar (HDL)dir. Aterogen zarrachalardagi, ayniqsa LDL dagi ortiqcha xolesterin arterial devorlarda yotqizilishni kuchaytiradi, ateroskleroz rivojlanishini rag‘batlantiradi va ishemik yurak kasalligi hamda insult xavfini oshiradi. Xolesterin ehtiyojining katta qismi jigarda sintez orqali qoplanadi, biroq parhezdagi iste’mol — ayniqsa hayvon yog‘lari — aylanayotgan aterogen lipoproteinlarni oshirishi mumkin, irsiy buzilishlar esa darajalarni yanada ko‘tarishi mumkin.
| O'lchov birligi | mg/dL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Routine adult lipid screening beginning at age ≥20 years, performed at least every 5 years, Clarification of an elevated total cholesterol result by delineating the contributing lipoprotein fractions, Ongoing monitoring during dietary modification and while receiving lipid-lowering therapy, Cardiovascular risk appraisal in the presence of established risk factors: tobacco use; age (men >45 years, women >55 years); hypertension (≥140/90 mm Hg); family history of premature atherosclerotic cardiovascular disease; known coronary heart disease, prior myocardial infarction, or stroke; diabetes mellitus; overweight or obesity; excess alcohol intake; high consumption of animal fats; and low physical activity, Selective pediatric screening (age 2–10 years) when there is a family history of hypercholesterolemia or early cardiovascular disease |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- anabolic steroids
- androgens
- corticosteroids
- high intake of animal fats
- pregnancy
- prolonged fasting
- smoking
- standing position
Pasaygan daraja
- allopurinol
- antifungal drugs
- cholestyramine
- clofibrate
- colchicine
- diet low in cholesterol and saturated fat, high in polyunsaturated fatty acids
- erythromycin
- estrogens
- intense physical activity
- statins
- supine position
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 2 mL (min 1 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |