Apolipoprotein A1
Kod:8019
| Kabi | Apolipoprotein A1 |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunoturbidimetriya
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Fast for at least 12 hours before the blood draw.
- Avoid vigorous exercise and significant emotional stress during the 30 minutes before collection.
- Do not smoke for the 30 minutes preceding collection.
Qanday foydalanish
Apolipoprotein A1 testi Apo A1 ni miqdoriy aniqlaydi va aterosklerotik yurak-qon tomir kasalligi hamda uning asoratlari xavfini baholashga yordam beradi. Ushbu o‘lchov HDL bilan bog‘liq funksiyani to‘laroq baholash uchun standart lipid tadqiqotlarini to‘ldiradi. Apolipoprotein B bilan birgalikda natijalar apoB/apoA1 nisbatini hisoblash uchun ishlatiladi; bu an’anaviy lipid panelidan tashqari stratifikatsiyani aniqlashtirishi mumkin bo‘lgan muqobil xavf markeri hisoblanadi. Tahlil lipidni pasaytiruvchi terapiya va boshqa aralashuvlar davomida kuzatuvni ham qo‘llab-quvvatlaydi. Keng qo‘llaniladigan sinonimlar: Alfa apolipoprotein va Apo A1.
Cheklovlar
Apolipoproteinlar lipoprotein zarralarining oqsil tarkibiy qismlari bo‘lib, xolesterin va triglitseridlarning eruvchanlashtirilishini hamda intravaskulyar transportini ta’minlaydi. Yuqori zichlikdagi lipoproteinlar, ko‘pincha "yaxshi" xolesterin deb ataladi, periferik to‘qimalardan jigarga ekskretsiya yoki metabolik o‘zgartirish uchun xolesterinni ko‘chirish orqali teskari xolesterin transportida ishtirok etadi; bu jarayon arteriya devorini aterosklerotik o‘zgarishlardan himoya qilishga yordam beradi. Apo A oilasida apolipoprotein A1 ustun shakl bo‘lib, apolipoprotein A2 kamroq miqdorda uchraydi. Apo A1 xolesterinni HDL zarralariga yuklaydigan yo‘llarni faollashtiradi va shu orqali HDL vositasidagi efflyuksni qo‘llab-quvvatlaydi. Apo A1 ning past konsentratsiyalari aterogenez ehtimolining yuqoriligi va nojo‘ya yurak-qon tomir hodisalari xavfining oshishi bilan bog‘liq.
| O'lchov birligi | g/L | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Documented hypercholesterolemia (elevated total cholesterol), Personal history of coronary artery disease, prior myocardial infarction, or previous ischemic stroke, Family history of premature atherosclerotic cardiovascular disease, Family history of hypercholesterolemia or premature cardiovascular disease, defined as myocardial infarction or stroke in a male first-degree relative <55 years or female first-degree relative <65 years, Evaluation for suspected hereditary apolipoprotein A deficiency, Suspected dyslipidemia attributable to apolipoprotein A1 deficiency, Risk stratification and follow-up during dietary modification and/or statin therapy when prior testing indicates high cardiovascular risk, Tobacco use, Age >45 years in men or >55 years in women, Hypertension (≥140/90 mm Hg), Diabetes mellitus, Overweight or obesity, Alcohol misuse, Diet high in animal fats, Low level of physical activity |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- alcohol (moderate)
- estrogens
- fibrates
- intense physical activity
- oral contraceptives
- phenobarbital
- pregnancy
- statins
Pasaygan daraja
- anabolic steroids
- androgens
- diuretics
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan |