Apolipoprotein B (apoB)
Kod:8020
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunoturbidimetriya
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Observe a minimum 12-hour fast before specimen collection.
- Avoid vigorous physical activity and minimize emotional stress for 30 minutes before the blood draw.
- Do not smoke during the 30 minutes prior to collection.
Qanday foydalanish
Apolipoprotein B testi lipid profili bilan birga aterosklerotik yurak-qon tomir kasalligi xavfini baholash uchun qo'llaniladi. Apolipoprotein A1 bir vaqtda buyurilganda, shifokorlar aterogen muvozanatning muqobil belgisi sifatida apoB/apoA1 nisbatini hisoblashlari mumkin. Triglitseridlar oshgan va hisoblangan LDL xolesterin ishonchliligi past bo'lganda apoB ni o'lchash ma'lumotli hisoblanadi. Ketma-ket apoB o'lchovlari parhezdagi o'zgarishlar va lipid pasaytiruvchi terapiyaning aterogen lipoprotein yuklamasiga ta'sirini kuzatish uchun ishlatilishi mumkin. Amaliyotda ishlatiladigan sinonimlar: Apo B, Apolipoprotein B-100 va Beta apolipoprotein.
Cheklovlar
Apolipoproteinlar lipoproteinlar tarkibida lipidlarni qon aylanishi orqali tashuvchi oqsillar karkasini tashkil etadi. Apolipoprotein B ikkita fiziologik izoforma ko'rinishida ishlab chiqiladi: jigarda sintezlanadigan va bosqichma-bosqich past zichlikdagi lipoproteinlarga (LDL) qayta tuziladigan juda past zichlikdagi lipoproteinlarga (VLDL) kiritiladigan apoB-100 hamda ichakda sintezlanadigan va ovqatdan kelgan lipidlarni jigarga tashuvchi xilomikronlarda mavjud bo'ladigan apoB-48. LDL zarralari xolesterinni periferik to'qimalarga yetkazadi. LDL ning doimiy yuqori bo'lishi ateromatoz blyashka hosil bo'lishini rag'batlantiradi, tomir kompliansini kamaytiradi va miokard infarkti hamda insult ehtimolini oshiradi. Qon aylanishidagi apoB-100 konsentratsiyasi LDL va VLDL kabi aterogen zarralar sonini aks ettiradi va faqat LDL xolesterin konsentratsiyasiga nisbatan aterosklerotik yurak-qon tomir kasalligi xavfi bilan yanada yaqinroq mos kelishi mumkin.
| Referens oraliq |
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|---|---|---|---|---|---|---|---|---|---|---|
| Ko'rsatmalar | Assessment for suspected deficiency or overproduction of apolipoprotein B, Individuals with a family history of premature coronary artery disease and/or dyslipidemia, Hypertriglyceridemia that compromises interpretation of calculated LDL cholesterol, Further risk stratification when previous testing suggests high atherosclerotic cardiovascular disease risk, Monitoring response to lipid-lowering medications (e.g., statins) and restriction of saturated animal fats in the diet, Evaluation in the presence of major atherosclerotic cardiovascular disease risk factors (smoking; age thresholds: men ≥45 years and women ≥55 years; blood pressure ≥140/90 mm Hg; family history of premature ASCVD; documented coronary artery disease or a history of myocardial infarction or stroke; diabetes mellitus; obesity; alcohol misuse; diets high in saturated fat; physical inactivity) |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- anabolic steroids
- androgens
- diet high in saturated fat and cholesterol
- diuretics
- obesity
- physical inactivity
- pregnancy
- smoking
Pasaygan daraja
- diet low in cholesterol and saturated fat and high in polyunsaturated fatty acids
- estrogens
- fibrates
- intensive physical exercise
- oral contraceptives
- phenobarbital
- prolonged fasting
- statins
- thyroxine
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |