Qaytarish

Alanin aminotransferaza (ALT/SGPT)

Kod:8030|CPT:84460|LOINC:1742-6

Sinonimlar
Глутамат-пируват-трансаминазаглутамат-пируват-трансаминаза в сывороткеСГПТALTAlanine aminotransferaseAlanine transaminaseGlutamic pyruvate transaminaseSerum glutamic-pyruvic transaminaseSGPTTransaminases
KabiALT (SGPT)

Tahlil ma'lumotlari

Tadqiqot usuli

  • Kinetik usul
  • Kinetik ultrabinafsha (UV) usul

Kutilayotgan natija topshirish vaqti

1 kun

Maxsus tayyorlik

  • Fast for 12 hours before the blood draw.
  • For 30 minutes before collection, avoid vigorous physical activity and minimize emotional stress.
  • Do not smoke during the 30 minutes preceding specimen collection.

Qanday foydalanish

Alanin aminotransferaza (ALT), shuningdek alanin transaminaza yoki zardob glutamat-piruvat transaminazasi (SGPT) sifatida ham ma’lum, virusli gepatit va toksik yoki dori-induksiyalangan gepatitni o‘z ichiga olgan gepatosellyulyar shikastlanishni aniqlash va kuzatishda, shuningdek sirroz va boshqa jigar kasalliklarini baholashda qo‘llanadi. ALT odatda AST bilan birga buyuriladi; ALT va AST oshishining darajasi va namunasi hamda ularning nisbati differensial tashxisni qo‘llab-quvvatlashi mumkin. O‘tkir gepatit A yoki B gumon qilinganda va gepatit Cda, aniq etiologiyani serologik tahlillar belgilaydi. Gepatitga xos fermentlar oshgan sharoitda virusli gepatit markerlarining doimiy yo‘qligi dori-induksiyalangan gepatitni ko‘rsatishi mumkin; preparat to‘xtatilgach yaxshilanish kuzatiladi. ALT yuqumli mononukleozda ham oshishi mumkin va yurak yetishmovchiligida ko‘tarilgan bo‘lishi mumkin.

Cheklovlar

ALT asosan gepatotsitlar ichida joylashadi. Gepatosellyulyar shikastlanish membrana o‘tkazuvchanligini oshiradi yoki hujayra nekrozini keltirib chiqaradi, bu ALTning qon aylanishiga o‘tishiga imkon beradi — ko‘pincha sariqlik kabi klinik namoyonlardan avval. ALT va AST odatiy jigar panellarining asosiy tarkibiy qismlaridir; AST bilan solishtirganda, ALT odatda gepatosellyulyar shikastlanish uchun ko‘proq spetsifik. Birgalikda talqin qilinganda, AST/ALT nisbati jigar kasalligining ehtimoliy etiologiyalarini taklif qilishga yordam beradi. ALT asosan jigarga xos bo‘lsa-da, ko‘tarilishlar jigardan tashqari holatlarda, jumladan skelet mushaklari kasalliklarida ham kuzatilishi mumkin.

O'lchov birligiIU/L
Referens oraliq
YoshErkaklarAyollar
≤1y1345
1y–120y0–500–35
Ko'rsatmalarAssessment of possible liver disease in patients reporting fatigue or asthenia, Loss of appetite (anorexia), Nausea and vomiting, Abdominal pain or progressive abdominal distention, New or worsening jaundice (icterus), Dark (“tea-colored”) urine or pale/acholic stools, Generalized pruritus, Prior viral hepatitis or recent exposure to hepatitis viruses, Heavy alcohol consumption or alcohol use disorder, Family history of liver disease, Use of medications or substances with hepatotoxic potential, Obesity, metabolic syndrome, or diabetes mellitus, Monitoring of liver disease during treatment

Natija og'ishlarining mumkin sabablari

Oshgan daraja

  • dermatomyositis
  • hemolysis
  • obesity
  • polymyositis
  • rhabdomyolysis
  • skeletal muscle injury

Namunangiz talablari

NamunangizZardob
ContainerOltin/yo'lbars qopqoqli probirka (SST, gel ajratgich)
Hajm1 mL (min 0.7 mL)
Saqlash tayyorlikXona harorati, Sovutilgan

References

Tonks DB. A study of the accuracy and precision of clinical chemistry determinations in 170 Canadian laboratories. Clin Chem. 1963 Apr; 9:217-233. PubMed 13985504