Qaytarish

Testosteron, so'lak

Kod:9026

Sinonimlar
Активная фракция тестостерона, биодоступный тестостерон.Active fraction of testosteroneBioavailable testosteroneFree testosteroneSalivary testosteroneUnbound testosterone
KabiTestosteron

Tahlil ma'lumotlari

Tadqiqot usuli

  • Ferment immunoanalizi (EIA)

Kutilayotgan natija topshirish vaqti

1 kun

Maxsus tayyorlik

  • Avoid food for 2–3 hours before collection; water is allowed.
  • Do not smoke during the 3 hours before collection.
  • For 3 hours before collection, avoid toothbrushing, flossing, toothpicks, or any activity that could injure the oral mucosa.
  • Confirm there is no gingival bleeding or oral mucosal injury before collection.
  • Review biotin use; stop high-dose biotin at least 72 hours prior to collection.

Qanday foydalanish

Testosteron, so'lak (so'lakdagi testosteron; erkin/biomavjud testosteronning surrogat ko'rsatkichi) androgen ortiqligi yoki yetishmovchiligini baholash hamda gonadal yoki adrenal manbaga oid o'sma faoliyatini tekshirish uchun qo'llaniladi. Erkaklarda natijalar gipogonadizm, gipopituitarizm, bepushtlik, erektil disfunktsiya va kech boshlanuvchi androgen yetishmovchiligini tashxislash va monitoring qilishga yordam beradi; shuningdek Klinefelter sindromini baholash va prostata saratonida antiandrogen terapiyani monitoring qilishni qo'llab-quvvatlaydi. Ayollarda tahlil hirsutizm, virilizatsiya, anovulyatsiya, amenoreya yoki oligomenoreya, polikistoz tuxumdon sindromi, androgen ajratadigan tuxumdon yoki buyrak usti bezi o'smalari va tug'ma buyrak usti bezi giperplaziyasi bo'yicha tekshiruvga hissa qo'shadi. Bolalarda o'lchov erta balog'atni ham o'z ichiga olgan pubertat va rivojlanish buzilishlarini baholashni qo'llab-quvvatlaydi. Jinsiy gormonlarni bog'lovchi globulin (SHBG) o'zgargan hollarda (masalan, gipotireoz, giperandrogenizm, semizlik), so'lakdagi testosteron biomavjud fraksiyani umumiy testosteronga qaraganda yaxshiroq aks ettirishi mumkin.

Cheklovlar

Testosteron sintezi lyuteinlashtiruvchi gormon tomonidan boshqariladi va asosan moyakning Leydig hujayralarida yuz beradi; tuxumdonlar va buyrak usti bezining qobig'i kichikroq hissa qo'shadi. Qon aylanishida gormonning aksariyati oqsillarga bog'langan: taxminan 60% jinsiy gormonlarni bog'lovchi globulin (SHBG) bilan mahkam bog'langan va sezilarli qismi albuminga bo'sh bog'langan bo'lib, faqat taxminan 2% to 3% erkin holatda qoladi. Bog'lanmagan fraksiya biologik faol bo'lib, hujayra membranalaridan o'tadi; so'lakdagi testosteron ushbu erkin komponentni yaqin aks ettiradi. Nishon to'qimalarda 5α-reduktaza testosteronni dihidrotestosteronga aylantiradi, u yanada kuchli androgenik ta'sirga ega; aromataza esa bir nechta joylarda estradiol hosil qiladi. Sekretsiya sirkadiy naqshga ega: ertalab konsentratsiya cho'qqilari kuzatiladi va erkaklarda yosh o'tishi bilan pasayadi. Ayollarda darajalar hayz sikli davomida o'zgaradi, homiladorlikda ortadi va menopauzadan keyin kamayadi. Androgen ortiqligi ayollarda virilizatsiya va boshqa giperandrogen belgilarini keltirib chiqaradi va o'g'il bolalarda erta balog'atga olib kelishi mumkin; yaqqol ko'tarilishlar tug'ma buyrak usti bezi giperplaziyasi yoki androgen ishlab chiqaruvchi o'smalardan kelib chiqishi mumkin. Yetishmovchilik erkaklarda gipogonadal namoyon bo'lishlarga sabab bo'ladi va ayollarda nospetsifik simptomlar bilan bog'liq bo'lishi mumkin. SHBG oshganda, biomavjud testosteron umumiy testosteronga qaraganda ko'proq kamayishi mumkin.

Referens oraliq
ErkaklarAyollar
1.75–7.810.1–0.75
Ko'rsatmalarSuspected or documented abnormalities in sex hormone–binding globulin (SHBG) levels, Evaluation of male infertility, Androgenic alopecia with suspected androgen excess, Acne vulgaris with a potential androgen contribution, Aplastic anemia, Androgen-secreting adrenal neoplasm, Monitoring during glucocorticoid therapy or androgen treatment, Erectile dysfunction, Reduced libido, Late-onset hypogonadism, Assessment for hypogonadism, Chronic prostatitis, Osteoporosis, Recurrent pregnancy loss, Female infertility, Seborrhea, Hirsutism, Anovulation, Amenorrhea, Oligomenorrhea, Abnormal uterine bleeding, Polycystic ovary syndrome, Congenital adrenal hyperplasia, Uterine leiomyoma, Endometriosis, Breast neoplasm, Pubertal disorders due to hypothalamic–pituitary dysfunction, Uterine hypoplasia, Breast hypoplasia

Natija og'ishlarining mumkin sabablari

Oshgan daraja

  • biotin (high dose)

Namunangiz talablari

NamunangizZardob
ContainerOltin/yo'lbars qopqoqli probirka (SST, gel ajratgich)

References

Dumesic DA. Hyperandrogenic anovulation: a new view of polycystic ovary syndrome. Postgrad Obstet Gynecol. 1995;15(13).

Morley JE, Perry HM 3rd. Androgen deficiency in aging men: role of testosterone replacement therapy. J Lab Clin Med. 2000;135:370-378.

Manni A, Pardridge WM, Cefalu W, et al. Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab. 1985;61:705.

Руководство по клинической эндокринологии. Под ред. Н.Т. Старковой. Санкт-Петербург: Питер; 1996.

Эндокринология. Под редакцией проф. П.Н. Боднара.