Dehidroepiandrosteron-sulfat, LC/MS-MS (Endocrine Sciences)
Kod:9031|CPT:82627|LOINC:2191-5
| Kabi | Dehidroepiandrosteron-sulfat, LCMS |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Suyuq xromatografiya va tandem mass-spektrometriya (LC-MS/MS)
- Kimyoluminessent immunoanaliz (CLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid eating for 2–3 hours before the blood draw; water is allowed.
- With the ordering clinician’s approval, stop steroid and thyroid hormone medications 48 hours before collection.
- Refrain from strenuous exercise and significant emotional stress for 24 hours prior to collection.
- Do not smoke during the 3 hours before collection.
- Testing is performed at Endocrine Sciences; specimens may be stored for up to 90 days.
Qanday foydalanish
DHEA Sulfate, LC/MS-MS (Endocrine Sciences), ya’ni dehidroepiandrosteron-sulfat (DHEA-S), buyrak usti bezlari androgen ishlab chiqarilishini baholaydi va androgen ortiqligining manbaini buyrak usti bezlari bilan tuxumdon yoki moyak kelib chiqishi o‘rtasida farqlashga yordam beradi. U hirsutizm va virilizatsiyani, shu jumladan polikistoz tuxumdonlar sindromini baholashda, shuningdek tug‘ma buyrak usti bezlari giperplaziyasi va buyrak usti bezlari o‘smalari/karsinomasiga o‘xshash adrenokortikal buzilishlarda qo‘llanadi. Tahlil bepushtlik va amenoreya bo‘yicha diagnostik tekshiruvni qo‘llab-quvvatlaydi hamda jinsiy rivojlanish buzilishlarini baholashga yordam beradi. DHEA-S darajalari odatda Addison kasalligida past bo‘ladi va gipopituitarizmda, odatda, oshmaydi.
Cheklovlar
Dehidroepiandrosteron-sulfat (DHEA-S) har ikkala jinsda uchraydigan androgen bo‘lib, kuchliroq androgenlar (testosteron, androstendion) hamda estrogenlarga aylanishi mumkin bo‘lgan prekursor hisoblanadi. Uning sintezi adrenokortikotrop gormon (ACTH) va boshqa gipofizar signallar tomonidan boshqariladi, bu esa uni buyrak usti bezlari funksiyasining foydali ko‘rsatkichi qiladi. Buyrak usti bezlari giperplaziyasi va buyrak usti bezlari o‘smalari/karsinomasi DHEA-S konsentratsiyalarini oshirishi mumkin. Erkaklarda yuqori darajalar klinik jihatdan simptomsiz bo‘lishi mumkin, ayollarda esa ular amenoreya va virilizatsiya bilan bog‘liq. Bolalar populyatsiyasida ortiqcha ishlab chiqarilish o‘g‘il bolalarda erta balog‘atga, qizlarda esa virilizatsiya, hirsutizm va menstrual sikl buzilishlariga hissa qo‘shadi.
| O'lchov birligi | mcg/dL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
Yoshingizga bog'liq | ||||
| Ko'rsatmalar | Suspected androgen excess with assessment of adrenal androgen production, Source localization of androgen excess (adrenal versus ovarian or testicular), Evaluation of amenorrhea, Workup of female infertility, Assessment of virilizing features in women (e.g., hirsutism, voice deepening, male‑pattern alopecia, acne), Evaluation of ambiguous genitalia or other disorders of sex development in girls, Assessment of precocious puberty in boys |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- dhea-s supplementation
- newborn period (physiologic)
Pasaygan daraja
- aging
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.2 mL (min 0.1 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |