Insulinga o‘xshash o‘sish omiliga bog‘lovchi oqsil-3 (IGFBP-3)
Kod:9058|CPT:83520|LOINC:2483-6
| Kabi | IGF-BP3 |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunokimyoluminometrik analiz (ICMA)
- Ferment bilan bog'langan immunosorbent analiz (ELISA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Infants younger than 1 year: avoid feeding for 30–40 minutes before the blood draw.
- Children 1–5 years: do not eat for 2–3 hours before collection.
- Age 5 years and older: fast for 8 hours; water is allowed.
- Refrain from vigorous exercise and minimize emotional stress for 30 minutes before collection.
- Do not smoke during the 30 minutes before the sample is taken.
- Confirm whether high-dose biotin (vitamin B7/B8, vitamin H, coenzyme R) is being taken.
- Stop biotin supplements for at least 72 hours prior to phlebotomy.
Qanday foydalanish
IGFBP-3 (IGF-bog‘lovchi oqsil 3) testi somatotrop o‘qni baholaydi, chunki uning ishlab chiqarilishi asosan o‘sish gormoniga bog‘liq va aylanmadagi darajalari pulsatsion GH ga nisbatan barqarorroqdir. O‘lchov pediatrik past bo‘y va gumon qilingan GH yetishmovchiligi, gipopituitarizm, akromegaliya va gigantizm, hamda gumon qilingan GHga insensitivlikni baholashda qo‘llaniladi. IGFBP-3 IGF-1 bilan birgalikda talqin qilinganda, rekombinant o‘sish gormoni bilan davolashni monitoring qilish va GH sekretsiya qiluvchi gipofiz adenomalari bo‘lgan bemorlarni operatsiyadan so‘ng va vaqt o‘tishi bilan, shu jumladan ad’yuvant medikamentoz terapiya yoki radioterapiya davrida va undan keyin kuzatishda ishlatiladi.
Cheklovlar
Qon aylanishida IGFBP-3 IGF-I va IGF-II ni bog‘laydi; eng ko‘p hollarda u kislota-labil subbirlik bilan ternar kompleks ko‘rinishida bo‘lib, IGF biofaolligini modulyatsiya qiladi va yarim parchalanish davrini uzaytiradi. Konsentratsiyalar yosh bilan o‘zgaradi: qiymatlar erta bolalik davrida oshadi, pubertat davrida cho‘qqiga chiqadi va kattalar hayotida biroz kamayadi. Oziqlanish holati hamda jigar va buyrak funksiyasi natijalarga ta’sir qiladi. Darajalar och qolish, surunkali oziqlanish yetishmovchiligi, jigar yetishmovchiligi va qandli diabetda kamayadi, surunkali buyrak yetishmovchiligida esa ortadi. IGFBP-3 sintezi o‘sish gormoniga bog‘liq va qisqa muddatli o‘zgaruvchanligi GH ning o‘ziga nisbatan kamroq bo‘lgani sababli, uning o‘lchovi GH yetishmovchiligi va ortiqligini baholash hamda GHga yo‘naltirilgan terapiyalarni monitoring qilish uchun qo‘shimcha ma’lumot beradi.
| O'lchov birligi | ng/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Childhood short stature when growth hormone deficiency is a concern., Adult findings compatible with GH deficiency, such as reduced bone mineral density, dyslipidemia, and decreased exercise tolerance., Evaluation for possible hypopituitarism., Monitoring response to recombinant growth hormone therapy., Clinical signs of gigantism or acromegaly, interpreted with growth hormone suppression testing., Postoperative follow-up after resection of a GH-secreting pituitary adenoma., Surveillance during and following adjuvant medical therapy or radiotherapy for GH-secreting pituitary tumors. |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- chronic renal failure
Pasaygan daraja
- biotin supplementation (high dose)
- chronic malnutrition
- diabetes mellitus
- fasting
- hepatic failure
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.2 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. J Clin Invest. 1986 Dec;78(6):1504-1512. PubMed 2431001
Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 1990 May;70(5):1292-1298. PubMed 1692331
Insulin-like Growth Factor Binding Protein-3 on the IDS iSYS, Device Code IS-4400, IFU Version 2011-11-29 V03. Fountain Hills, Ariz: Immunodiagnostic Systems Inc (IDS Inc).
Rosenfeld RG, Wilson DM, Lee PD, Hintz RL. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr. 1986 Sep;109(3):428-433. PubMed 3746530