I-tip prokollagenning intakt N-terminal propeptidi (P1NP)
Kod:9071|CPT:82523|LOINC:47255-5
| Kabi | I-tip kollagen propeptidi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunokimyoluminometrik analiz (ICMA)
- Elektrokimyoluminessent immunoanaliz (ECLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Infants younger than 1 year: delay feeding for 30–40 minutes before the blood draw
- Children 1–5 years: do not eat for 2–3 hours prior to collection
- All other patients: fast for 8 hours; water is allowed
- Avoid strenuous physical activity and marked emotional stress for 24 hours before collection
- Do not smoke during the 30 minutes preceding collection
- Stop high-dose biotin supplements for at least 72 hours before collection
Qanday foydalanish
I-tip prokollagenning intakt N-terminal propeptidi (P1NP; PINP yoki procollagen type I N-terminal propeptide deb ham ataladi) tahlili yangi I-tip kollagen sintezini aks ettiruvchi hosil bo'lish markerini miqdoriy baholaydi. U suyak hosil bo'lish holatining boshlang'ich tavsiflanishini qo'llab-quvvatlaydi va osteoporozda, jumladan teriparatid va boshqa suyak-faol dori vositalari bilan davolanayotgan bemorlarda, davoga javobni keyingi baholashni ta'minlaydi. P1NP sinovi osteoporoz, Paget kasalligi va suyakka metastatik zararlanishning kuzatuviga kiritiladi; bu holatlarda u skelet metastazlari faolligini baholashga yordam berishi mumkin. Ayrim kontekstlarda P1NP o'lim xavfini baholash uchun ham qo'llanilgan.
Cheklovlar
Skelet to'qimasi doimiy remodellasiyada bo'ladi: osteoklastlar vositasidagi rezorbsiya osteoblastlar boshqaradigan hosil bo'lish bilan muvozanatlanadi va kalsiy gomestazi hamda endokrin signallar tomonidan modulyatsiyalanadi. I-tip kollagen suyak matriksining asosiy organik komponentidir. U yetilish jarayonida fermentativ ravishda ajratib tashlanadigan N- va C-terminal propeptidlarni o'z ichiga olgan prokollagen ko'rinishida sintezlanadi; intakt N-terminal propeptid (P1NP) qon aylanishida nisbatan barqaror bo'lib, yangi kollagen qo'yilishini kuzatib boradi. Shu bois, P1NP suyak hosil bo'lishining va, keng ma'noda, umumiy suyak almashinuvi markeridir. P1NP postmenopauzal osteoporoz, Paget kasalligi va suyakka metastatik zararlanish kabi metabolik suyak kasalliklarini baholashda suyak rezorbsiyasi markerlari va suyak mineral zichligi o'lchovlarini to'ldiradi. Konsentratsiyalar sutkalik o'zgaruvchanlikka ega bo'lib, kechasi yuqoriroq bo'ladi; solishtirish uchun keyingi namunalar kunning bir xil vaqtida yig'ilishi kerak. P1NP jigar tomonidan klirensga uchraydi, va og'ir gepatik disfunktsiya metabolik klirensning kamayishi tufayli aylanuvchi darajalarni oshirishi mumkin.
| O'lchov birligi | ng/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Establish a pretreatment baseline and reassess at 3–6 months after starting anti-osteoporotic therapy to evaluate response, Diagnostic workup and longitudinal monitoring in osteoporosis, Paget disease, and malignant disease with bone metastases |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- nighttime collection
- severe liver disease
Pasaygan daraja
- biotin supplementation (high-dose)
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.5 mL (min 0.4 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Markus J Seibel. Biochemical Markers of Bone Turnover Part I: Biochemistry and Variability. Clin Biochem Rev. 2005;26(4):97-122. PMCID: PMC1320175.