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GM1 IgG Autoantibody

Code:11004|CPT:83520|LOINC:43240-1

Synonyms
Иммуноглобулины (антитела) класса G.Anti-GM1 IgGAnti-ganglioside GM1 IgGGanglioside GM1 IgG autoantibodyIgG, total, serumImmunoglobulin G
IncludesGM1 IgG Autoantibodies

Analysis details

Methodology

  • Enzyme-linked immunosorbent assay (ELISA)

Expected Turnaround Time

1 day

Special Instructions

  • Testing is not offered for patients in New York state.
  • Do not eat for 2–3 hours before the blood draw; water is allowed.
  • Avoid physical exertion and emotional stress for 30 minutes before collection.
  • Do not smoke during the 3 hours prior to phlebotomy.

How to use

The GM1 IgG Autoantibody test—also referred to as Anti-GM1 IgG or anti‑ganglioside GM1 IgG—provides a qualitative determination of IgG class autoantibodies to GM1 in serum. It is used when assessment of autoantibodies against ganglioside targets is indicated. Testing is performed by enzyme-linked immunosorbent assay (ELISA) and reported qualitatively.

Limitations

GM1 (monosialotetrahexosylganglioside) is a defined ganglioside antigen, and this assay evaluates IgG autoantibodies directed against that target in serum. The method is enzyme-linked immunosorbent assay (ELISA), and results are qualitative. Findings are interpreted in conjunction with clinical assessment and other laboratory data as appropriate.

Unit%
Reference interval
MinMax
8.1717.05
Indications—

Specimen Requirements

SpecimenSerum
ContainerGold/Tiger Top (SST, Gel Separator)
Volume0.3 mL (min 0.1 mL)
Storage InstructionsFrozen

References

Chalah MA, et al. A comparison of four commercial tests for detecting anti-ganglioside antibodies in patients with well-characterized dysimmune peripheral neuropathies. 2016.Han TH, Kim DY, Park DW, Moon JH. Transient Isolated Lower Bulbar Palsy With Elevated Serum Anti-GM1 and Anti-GD1b Antibodies During Aripiprazole Treatment. Pediatr Neurol. 2017 Jan;66:96-99. PubMed 28341090Islam Z, Jacobs BC, van Belkum A, et al. Axonal variant of Guillain-Barré syndrome associated with Campylobacter infection in Bangladesh. Neurology. 2010 Feb 16;74(7):581-587. PubMed 20157160Kollewe K, Wurster U, Sinzenich T, et al. Anti-ganglioside antibodies in amyotrophic lateral sclerosis revisited. PLoS One. 2015 Apr 14;10(4):e0125339. PubMed 25875836Lei T, Siu KL, Kok KH, et al. Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus. Vaccine. 2012 Mar 30;30(16):2605-2610. PubMed 22342549Mani B, et al. The Frequency of anti-Ganglioside Antibodies in Blood Donors Compared to Control Groups and Guillain-Barré Syndrome Patients. Poster presented at DAS, Dresden (GE). 2010.Sharma MB, Chaudhry R, Tabassum I, et al. The presence of Mycoplasma pneumonia infection and GM1 ganglioside antibodies in Guillain-Barré syndrome. J Infect Dev Ctries. 2011 Jul 4;5(6):459-474. PubMed 21727645Uncini A, Yuki N. Electrophysiologic and immunopathologic correlates in Guillain-Barré syndrome subtypes. Expert Rev Neurother. 2009 Jun;9(6):869-884. PubMed 19496690Uysalol M, Tatli B, Uzel N, Citak A, Aygün E, Kayaoğlu S. A Rare Form of Guillain-Barré Syndrome: A Child Diagnosed with Anti-GD1a and Anti-GD1b Positive Pharyngeal-Cervical-Brachial Variant. Balkan Med J. 2013 Sep;30(3):337-341. PubMed 25207134Wurster U, et al. Ganglioside Antibodies in Amyotrophic Lateral Sclerosis. Poster presented at DAS, Dresden (GE). 2009.

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