ВПЧ Квант-21 (6,11,16,18,26,31,33,35,39,44,45,51,52,53,56,58,59,66,68,73,82)

Human papillomavirus (HPV) high‑risk genotypes DNA, real‑time PCR genotyping is used to identify infection with oncogenic HPV types and to determine the specific genotype present. The assay supports evaluation for persistence of a particular HPV type and assists in assessing carcinogenic risk in women with cervical epithelial dysplasia. Common search terms include HPV high‑risk DNA test and HPV genotyping.

Human papillomaviruses infect squamous epithelium of the skin and mucosal surfaces and circulate widely in the population. Transmission occurs through close contact, most commonly sexual, with possible vertical transmission from an infected mother. Individuals may harbor multiple HPV types concurrently. Factors associated with acquisition and persistence include early sexual debut, multiple partners, immunosuppression, use of oral contraceptives, nutritional deficiency, concurrent sexually transmitted infections, tobacco use, and urban residence. The incubation period ranges from approximately 2 months to 2–10 years. Many infections remain clinically silent; colposcopic, cytologic, and histologic examinations may appear normal despite viral presence. About 30% of infections clear spontaneously within 6–12 months. Latent infection is identified by molecular methods. Symptomatic disease may manifest with benign lesions such as papillomas, cutaneous warts, and anogenital condylomas. In children, laryngeal papillomatosis may occur, and trophoblastic involvement has been associated with spontaneous abortion. Integration of HPV DNA into host cell genomes promotes dysplasia and neoplasia, particularly in the cervical transformation zone. High‑risk HPV types include 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68; infection can be associated with bowenoid papulosis and cervical squamous intraepithelial neoplasia. Real‑time PCR detects HPV DNA in clinical specimens and enables genotype identification by amplifying type‑specific genomic targets.