Sm (Smith) antigeniga qarshi antitanalar (Anti-Sm) (RDL)
Kod:16005|CPT:86235|LOINC:11090-8
| Kabi | Sm (Smith) antigeniga qarshi antitanalar (Anti-Sm) (RDL) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment immunoanalizi (EIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Anti-Smith antitanasi (anti-Sm) testi tizimli qizil yuguruk uchun juda yuqori spetsifik serologik marker bo‘lib, sezgirligi cheklangan (SLE holatlarining taxminan 20%–30%). Musbat antinuklear antitana (ANA) skriningi mavjud bo‘lgan sharoitda, anti-Sm natijalari SLE tashxisini asoslashga va tizimli autoimmun biriktiruvchi to‘qima kasalliklari orasidagi differensial tashxisni aniqlashtirishga yordam beradi. Anti-Sm reaktivligi SLE dan tashqarida kam uchraydi; faqat vaqti-vaqti bilan monoklonal gammopatiyalar va uveitda qayd etilgan. Ushbu tahlil odatda ekstraktlanadigan yadro antigenlari (ENA) antitanalari va boshqa ANA-spetsifik antitanalar bilan birga ko‘rib chiqilib, serologik naqshlarni talqin qilishda yordam beradi.
Cheklovlar
Anti-Sm (Smith) antitanalar U1, U2 va U4 kichik yadro ribonukleoproteinlari bilan bog‘liq antigenlarni tan oladi. Ushbu spetsifiklik ularning tizimli qizil yuguruk bilan kuchli assotsiatsiyasini va boshqa tizimli autoimmun kasalliklarda kam uchrashini asoslaydi. Anti-Sm holati SLEni klassifikatsiya qilish mezonlariga hissa qo‘shadi. Antitana konsentratsiyalari tizimli qizil yugurukning kasallik faolligi bilan korrelyatsiyalanmaydi va kasallik kechishini monitoring qilish uchun mos emas. Shunga muvofiq, anti-Sm testlari diagnostik klassifikatsiya va differensial tashxis uchun ishlatiladi; serial kasallik kuzatuvi uchun emas.
| Referens oraliq |
| ||||
|---|---|---|---|---|---|
| Ko'rsatmalar | Positive ANA by HEp-2 indirect immunofluorescence or an equivalent screening method., Clinical picture consistent with a systemic autoimmune connective tissue disorder (for example, photosensitivity, inflammatory arthritis, Raynaud phenomenon, leukopenia, autoimmune hemolytic anemia, persistent fever, weight loss, or myalgia)., Clarifying the differential diagnosis when systemic lupus erythematosus or overlap syndromes are suspected., Follow-up serologic assessment in patients with known or suspected systemic connective tissue disease. |
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.3 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Fischbach F.T., Dunning M.B. A Manual of Laboratory and Diagnostic Tests. 8th ed. Lippincott Williams & Wilkins; 2008:1344.
Wilson D. McGraw-Hill Manual of Laboratory and Diagnostic Tests. 1st ed. McGraw-Hill; 2007:666.
Sabatine M. Pocket Medicine. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008.