Anti-Scl-70 antikorlari (RDL)
Kod:16008|CPT:86235|LOINC:5348-8
| Kabi | Anti-Scl-70 antikorlari (RDL) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment bilan bog'langan immunosorbent analiz (ELISA)
- Immunoblotting
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Refrain from smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Anti-Scl-70 (anti-topoizomeraza I) antikor testi sistem skleroz tashxisini qo‘llab-quvvatlaydi va ANA-spesifik hamda ENA antikor testlari kontekstida sklerodermiyani boshqa sistem autoimmun biriktiruvchi to‘qima kasalliklaridan farqlashga yordam beradi. Natijalar musbat ANA ning ahamiyatini aniqlashtirishi va klinik xususiyatlar sistem autoimmunitetni ko‘rsatsa, baholashni yo‘naltirishi mumkin. Anti-Scl-70 antikorlari sklerodermiya bilan kasallangan bemorlarning taxminan 20% ida qayd etiladi; chastota klinik subtip va populyatsiyaga qarab farq qiladi. Ushbu antikorlar overlap sindromlarda ham, yakka holda yoki boshqa avtoantikor spetsifikliklari bilan birga uchrashi mumkin.
Cheklovlar
Ekstraksiyalanadigan yadro antigenlariga (ENA) qarshi antikorlar eruvchan yadro ribonukleoprotein komponentlariga yo‘naltirilgan. Ular orasida DNK topoizomeraza I (Scl-70) ga IgG sistem skleroz uchun yuqori spetsifiklik ko‘rsatadi. Musbatlik ko‘proq diffuz teri zararlanishi bilan bog‘liq va interstitsial o‘pka kasalligi xavfining ortishi bilan assotsiatsiyalangan. Avtoantikor spetsifikliklari yakka holda paydo bo‘lishi yoki overlap sindromlarda boshqa antikorlar bilan birga kuzatilishi mumkin.
| Referens oraliq |
| ||||
|---|---|---|---|---|---|
| Ko'rsatmalar | Positive ANA by indirect immunofluorescence on HEp-2 substrate, Evaluation of patients with features suggestive of systemic autoimmune disease, including persistent fever, unintentional weight loss, myalgia, inflammatory arthropathy, photosensitivity, Raynaud phenomenon, leukopenia, or hemolytic anemia, Longitudinal monitoring of systemic connective tissue diseases |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- aminosalicylic acid
- isoniazid
- methyldopa
- penicillin
- propylthiouracil
- streptomycin
- tetracycline
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.3 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Nazarenko GI, Kishkun A. Clinical assessment of laboratory test results. Moscow: Meditsina; 2000. 533 p.
Fischbach FT, Dunning MB. A Manual of Laboratory and Diagnostic Tests. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2008.
Wilson D. McGraw-Hill Manual of Laboratory and Diagnostic Tests. 1st ed. Normal, Illinois; 2007.
Sabatine MS. Pocket Medicine. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008.