Antikardiolipin antitanachalar, IgG va IgM
Kod:16018
Tahlil ma'lumotlari
Tadqiqot usuli
- Kimyoluminessent immunoanaliz (CLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before your blood draw.
Qanday foydalanish
Antikardiolipin antitanachalar, IgG va IgM lupus antikoagulyanti va anti–beta-2 glikoprotein I bilan birga gumon qilingan antifosfolipid sindromini (APS) baholash uchun qo‘llanadi. Ko‘pincha antikardiolipin antitanachalari (aCL) deb ataladigan ushbu tahlil APS gumon qilinayotgan, jumladan sistemali qizil volchanka kabi autoimmun kasalliklarga ega bemorlarda venoz yoki arterial tromboz hamda homiladorlikdagi asoratlar xavfini baholashga yordam beradi. APS differensial tashxisida ushbu antifosfolipid antitanachalarni o‘lchashni diagnostik tekshiruvga kiritish trombotik xavf va akusherlik asoratlarini yanada aniqroq tavsiflashga yordam beradi.
Cheklovlar
Antikardiolipin antitanachalar antifosfolipid antitanachalar oilasining bir qismi bo‘lib, kardiolipin bilan kompleks hosil qilganda beta-2 glikoprotein I ni taniydi. Ularning mavjudligi venoz va arterial tromboz hamda noxush homiladorlik oqibatlari bilan bog‘liq; bu klinik hodisalar antifosfolipid antitanachalarning laborator dalillari bilan birga kuzatilsa, holat antifosfolipid sindromi (APS) deb ataladi. Tekshiruvni keskin trombotik epizoddan tashqarida o‘tkazish ma’qul, chunki aCL vaqtinchalik bo‘lishi mumkin; davomiyligini tasdiqlash uchun 12 haftadan so‘ng takroriy test tavsiya etiladi. aCL testlari, odatda, analitik sezgirligi yuqoriroq, biroq spetsifikligi pastroq bo‘ladi, chunki vaqtinchalik ijobiylik infeksiyalar va boshqa holatlar bilan birga kuzatilishi mumkin; barqaror reaktivlik APS ehtimolini oshiradi. aCL yakka o‘zi APS klassifikatsiyasini belgilamaydi; laborator mezonlarga shuningdek lupus antikoagulyanti va anti–beta-2 glikoprotein I kiradi, va uch karra ijobiylik kelajakdagi trombotik xavfning yuqoriligi bilan bog‘liq. Serial o‘lchovlar davolash monitoringi uchun foydali emas, chunki titrlar kasallik faolligidan mustaqil ravishda o‘zgarishi mumkin; qayta tekshirish klinik holat sezilarli o‘zgarganida amalga oshiriladi. Revmatoyid omil IgM aCL natijalarini soxta ravishda oshirishi mumkin va talqin qilishda e’tiborga olinishi lozim. aCL ijobiyligi nontreponemal sifilis skriningi (RPR)da soxta ijobiy javobga olib kelishi mumkin, bu esa tasdiqlovchi testlarni talab qiladi.
| Referens oraliq |
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| Ko'rsatmalar | First-time venous or arterial thrombosis before age 50 years, or thrombosis occurring at an atypical anatomic site, Recurrent pregnancy loss defined as three or more consecutive spontaneous miscarriages before 22 weeks' gestation, Clinical findings compatible with antiphospholipid syndrome, including valvular heart disease (vegetations, thickening, or dysfunction), livedo reticularis, nephropathy, thrombocytopenia, preeclampsia, chorea, or epilepsy, Thrombosis or pregnancy loss in the context of an autoimmune disorder (e.g., systemic lupus erythematosus), Evaluation of a prolonged activated partial thromboplastin time (aPTT) in conjunction with lupus anticoagulant testing, Positive nontreponemal syphilis screening result (RPR) that requires confirmatory clarification |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- hepatitis
- hiv infection
- rheumatoid factor
- varicella-zoster virus infection
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
References
Devreese K, Hoylaerts MF. Challenges in the diagnosis of the antiphospholipid syndrome. Clin Chem. 2010 Jun;56(6):930-40.
Ortel TL. Antiphospholipid syndrome: laboratory testing and diagnostic strategies. Am J Hematol. 2012 May;87 Suppl 1:S75-81.
Lakos G, Favaloro EJ, Harris EN, Meroni PL, Tincani A, Wong RC, Pierangeli SS. International consensus guidelines on anticardiolipin testing: report from the 13th International Congress on Antiphospholipid Antibodies. Arthritis Rheum. 2012 Jan;64(1):1–10.
Chernecky CC, Berger BJ. Laboratory Tests and Diagnostic Procedures. 5th ed. Saunders Elsevier; 2008.