D-dimer
Kod:3008|CPT:85379|LOINC:48065-7
| Kabi | D-dimer |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunoturbidimetrik analiz
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- If hematocrit is greater than 55%, adjust the sodium citrate volume in the collection tube according to coagulation collection procedures
- Avoid high-fat foods for 24 hours before the blood draw
- Refrain from strenuous exercise and minimize emotional stress for 30 minutes before collection
- Do not smoke during the 30 minutes prior to specimen collection
Qanday foydalanish
D-dimer testi yuqori bo‘lmagan klinik oldindan ehtimollik bilan birga chuqur vena trombozi va o‘pka tromboemboliyasini istisno qilishga yordam berish uchun qo‘llanadi; bu sharoitda belgilangan chegara qiymatidan past natija qo‘shimcha venoz tromboemboliyani tekshirishni oldini olishi mumkin. Analiz shuningdek disseminirlangan intravaskulyar koagulyatsiyani baholashni qo‘llab-quvvatlaydi. Fibrin parchalanish mahsuloti o‘lchovi sifatida D-dimer tromb hosil bo‘lishini baholash va tromboembolik kasallikda antikoagulyant terapiyani kuzatish uchun yordamchi vosita bo‘lib xizmat qiladi; talqin klinik topilmalar va boshqa laborator ma’lumotlar bilan integratsiyalangan holda amalga oshiriladi.
Cheklovlar
D-dimer plazmin tromb ichidagi kross-bog‘langan fibrinni degradatsiya qilganda ajralib chiqadi va koagulyatsiya hamda fibrinolitik tizimlar faolligining ko‘rsatkichini beradi. Uning konsentratsiyasi fibrinolitik faollikni va bilvosita tarzda trombin hosil bo‘lishi miqyosini aks ettiradi. Tromboz endotelial shikastlanish, qon oqimining stazi yoki g‘ayritabiiy shear kuchlanishi oqibatida yuzaga kelishi mumkin va operatsiyadan keyingi holatlar, infeksiya va venoz yetishmovchilik kabi holatlarda kuzatiladi. Fiziologik oshishlar homiladorlikda, eng ko‘p uchinchi trimestrda kuzatiladi; mavjud tadqiqotlar D-dimer konsentratsiyasi bilan homiladorlikning noxush natijalari o‘rtasida izchil bog‘liqlikni ko‘rsatmagan. Yuqori qiymatlar shifoxonaga yotqizilgan bemorlarda va ko‘plab notrombotik holatlarda odatiy bo‘lib, spesifiklikni cheklaydi. D-dimer klinik taqdimot va qo‘shimcha laborator natijalar kontekstida talqinni talab qiladigan yordamchi testdir. Normal konsentratsiyalar subsegmentar yoki periferik o‘pka emboliyasida, distal chuqur vena trombozida yoki tromb hosil bo‘lgandan so‘ng namuna olish kechiktirilganida fibrin parchalanish mahsulotining klirensi tufayli kuzatilishi mumkin. Oldindan ehtimolligi yuqori bo‘lgan bemorlarda o‘pka emboliyasini istisno qilish uchun D-dimerdan foydalanish o‘rnatilmagan.
| O'lchov birligi | mg/L | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Workup of suspected deep vein thrombosis presenting with unilateral leg swelling and pain, Assessment of possible pulmonary embolism with acute dyspnea, pleuritic chest pain, tachycardia, cough, or hemoptysis, Evaluation for disseminated intravascular coagulation in the setting of bleeding and organ dysfunction, Monitoring the effect of anticoagulant therapy in venous thromboembolism |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- aortic aneurysm
- disseminated intravascular coagulation
- disseminated malignancies
- heterophilic antibodies
- liver cirrhosis
- pneumonia
- pregnancy
- sepsis
- severe infections
- severe skin infections
- sickle cell disease
- trauma or recent surgery
Pasaygan daraja
- delayed sampling after thrombosis onset
- distal deep vein thrombosis
- subsegmental or peripheral pulmonary embolism
Namunangiz talablari
| Namunangiz | Plazma |
|---|---|
| Container | Och ko'k qopqoqli probirka (3,2% natriy sitrat) |
| Hajm | 2 mL (min 1 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |