Zonulin, najas
Kod:6010
| Kabi | Zonulin |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment immunoanalizi (EIA)
Kutilayotgan natija topshirish vaqti
3 kun
Maxsus tayyorlik
- Do not use laxatives, rectal suppositories, or oils for 72 hours before collecting the stool specimen.
- If clinically appropriate and agreed upon with the ordering clinician, hold medications that affect intestinal motility (eg, belladonna, pilocarpine) and agents that change stool color (iron, bismuth, barium sulfate) for 72 hours prior to collection.
Qanday foydalanish
Zonulin, najas testi ichak o‘tkazuvchanligining ortishini, ichak o‘tkazuvchanligi markeri va haptoglobin 2 prekursori bo‘lgan fekal zonulinni miqdoran aniqlash orqali baholaydi. U seliak kasalligi va ayrim autoimmun holatlarni, jumladan 1-tur qandli diabet, ko‘p skleroz va revmatoyid artritni baholashni qo‘llab-quvvatlaydi. Seliak kasalligida ketma-ket o‘lchovlar glyutensiz parhezga javobni monitoring qilishga yordam berishi mumkin.
Cheklovlar
Ichak epiteliy hujayralari orasidagi mahkam birikmalar (zonula occludens) oziqa moddalari va antigenlarning paratsellyulyar o‘tishini nazorat qiladi. Zonulin epiteliy retseptoriga bog‘lanadi va ushbu birikmalarni ochadigan signallanishni boshlaydi, natijada o‘tkazuvchanlik ortadi; ushbu yo‘l zonula occludens toksini mexanizmining inson analogini ifodalaydi. Zonulinning oshishi faol seliak kasalligida ko‘rsatilgan va 1-tur qandli diabetda xabar qilingan; oshgan o‘tkazuvchanlik klinik jihatdan yaqqol kasallikdan avval yuzaga kelishi mumkin. Zonulin yo‘lining farmakologik ingibitsiyasi eksperimental sharoitlarda o‘tkazuvchanlikni kamaytirgan. Yuqori zonulin konsentratsiyalari va to‘siq disfunksiyasi bir qator autoimmun kasalliklar hamda yallig‘lanishli ichak kasalligi bilan bog‘langan.
| O'lchov birligi | ng/mL |
|---|---|
| Referens oraliq | — |
| Ko'rsatmalar | Assessment of suspected increased intestinal permeability (leaky gut)., Adjunctive evaluation in patients undergoing workup for celiac disease., Supportive testing in the context of autoimmune conditions such as type 1 diabetes, multiple sclerosis, or rheumatoid arthritis., Monitoring changes in celiac disease during adherence to a gluten-free diet. |
Namunangiz talablari
| Namunangiz | Najis |
|---|---|
| Container | Steril najas idishi |