Mochevina azoti
Kod:7014
| Kabi | Mochevina azoti |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ureaza usuli
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not consume alcohol during the 24 hours before starting the collection.
- For 12 hours before collection, avoid spicy or salty foods and items that can discolor urine, such as beets or carrots.
- If clinically acceptable, hold diuretics for 48 hours before collection.
- During the 24-hour urine collection, avoid strenuous physical activity and significant emotional stress.
Qanday foydalanish
Mochevina azoti, 24 soatlik siydik azot balansini va oqsil parchalanishi darajasini baholash uchun qo‘llanadi; bu enteral yoki parenteral ovqatlanayotgan og‘ir ahvoldagi shaxslarda kundalik oqsil va azot ehtiyojini hisoblashga imkon beradi. Test ko‘pincha siydikdagi mochevina azoti (UUN) deb ataladi va oqsil ta’minotini moslashtirish uchun ovqatlantirish qo‘llab-quvvatlash rejalari tarkibiga kiritiladi. Qon zardobida mochevina ko‘tarilganda, siydikdagi mochevina azoti buyrak ekskresiyasini baholashga yordam beradi va buyrak klirensining pasayishini katabolik holatlar yoki yuqori oqsil qabuliga bog‘liq mochevina hosil bo‘lishining ortishidan farqlashga imkon beradi. Talqin klinik holat kontekstida va, zarur bo‘lganda, qon zardobidagi mochevina azoti (qondagi mochevina azoti, BUN) va kreatinin bilan birga amalga oshiriladi.
Cheklovlar
Mochevina jigar tomonidan aminokislotalar katabolizmida hosil bo‘ladigan ammiakdan urea sikli orqali sintez qilinadi va buyraklar orqali chiqariladi. Mochevina glomerulada erkin filtrlanadi; uning taxminan uchdan bir qismi passiv qayta so‘riladi, bu jarayon siydik oqimi past bo‘lganda kuchayadi. Siydikdagi mochevina ajralishi ratsiondagi oqsil iste’moliga proportsional bo‘lib, odatda umumiy siydikdagi azotning taxminan 90% ini tashkil etadi. Yuqori siydikdagi mochevina ajralishi salbiy azot balansini ko‘rsatadi va operatsiyadan keyingi katabolizm, gipertireoz yoki yuqori me’da-ichak yo‘li qon ketishidan so‘ng ichak orqali qon oqsillarining so‘rilishi bilan kuzatiladi. Ajralishning kamayishi ijobiy azot balansini aks ettiradi va buyrak kasalliklarida, jigar tomonidan mochevina sintezining buzilishida — jumladan urea sikli fermentlari yetishmovchiligida — hamda o‘sish gormoni, testosteron va insulin kabi ayrim gormonlar ta’siri ostida uchraydi. Siydikdagi mochevinaning past konsentratsiyasi, shuningdek, buyrak perfuziyasi pasayishi yoki suvsizlanish sharoitlarida naychachalar orqali qayta so‘rilishning ortishi natijasida, jumladan qon ketishi, shok, suvsizlanish, kuyishlar yoki yurak yetishmovchiligida va buyrak arteriyalarining aterosklerozi bo‘lgan keksalarda rivojlanishi mumkin. Natijalar klinik manzara bilan va, zarur hollarda, qon zardobidagi mochevina azoti va kreatinin bilan birga talqin qilinadi.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Evaluate nitrogen balance and protein catabolism in critically ill patients receiving enteral or parenteral nutrition., Guide calculation of daily protein and nitrogen requirements for intensive care patients on nutritional support., Assess renal excretory function when serum urea is elevated, including in kidney diseases such as pyelonephritis, glomerulonephritis, renal amyloidosis, renal tuberculosis, and in acute or chronic renal failure. |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- cortisone
- dexamethasone
- hydrocortisone
- prednisolone
- quinine
- salicylates
- thyroxine
Pasaygan daraja
- anabolic steroids
- growth hormone
- insulin
- nephrotoxic drugs
- testosterone
Namunangiz talablari
| Namunangiz | Urina |
|---|---|
| Container | Steril siydik idishi |
| Saqlash tayyorlik | Sovutilgan |
References
Kamyshnikov VS. Clinical laboratory tests from A to Z and their diagnostic profiles. Reference manual. Moscow: MEDpress-inform; 2007. 3rd ed.
Marshall J. Clinical Biochemistry. Moscow; St. Petersburg: Binom; Nevskii Dialekt; 2000.
Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011: chap 116.