Glikatsiyalangan gemoglobin (HbA1c)
Kod:8007|CPT:83036|LOINC:4548-4
| Kabi | Gemoglobin A1c |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Roche Tina-quant immunoturbidimetrik analizi
- Yuqori samarali suyuq xromatografiya (HPLC)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid food for 2–3 hours before the blood draw; water is allowed.
- Refrain from strenuous exercise and minimize emotional stress during the 30 minutes before collection.
- Do not smoke within 30 minutes of specimen collection.
Qanday foydalanish
Gemoglobin A1c testi (glikatsiyalangan gemoglobin, glikogemoglobin) diabetga chalingan odamlarda surunkali glikemik nazoratni baholash uchun qo'llaniladi. U joriy terapiya maqsad ko'rsatkichlariga erishayotganini aniqlashga yordam beradi va davolashni moslashtirish bo'yicha qarorlarni qo'llab-quvvatlaydi, shuningdek yangi tashxis qo'yilganlarda barqaror giperglikemiyani aniqlashi mumkin. Tegishli klinik va laborator ma'lumotlar bilan birgalikda qo'llanganda, HbA1c qandli diabet tashxisini va prediabetli shaxslarni aniqlashni qo'llab-quvvatlaydi.
Cheklovlar
HbA1c vaqtga og'irlangan o'rtacha glikemiyani aks ettiradi va o'tkir o'zgarishlar yoki kun ichidagi o'zgaruvchanlikni tutib olmaydi. Tafsirlash eritrotsitlar almashinuvi yoki gemoglobin tarkibini o'zgartiradigan omillarni hisobga olishni talab etadi. Eritrotsitlar yashash muddatining qisqarishi — masalan, gemolitik anemiya, o'tkir yoki surunkali qon yo'qotish, yoki homiladorlikda — haqiqiy amaldagi glikemiyaga nisbatan pastroq HbA1c qiymatlariga olib kelishi mumkin. Gemoglobin variantlari eritrotsitlar umr davomiyligiga yoki in vivo glikatsiyaga ta'sir qilishi mumkin. HbA1c va kuzatilgan plazma glyukozasi o'rtasida yaqqol nomuvofiqlik aniqlansa, ADA tavsiyalariga muvofiq gemoglobin varianti bor-yo'qligini baholash va glyukozaga asoslangan muqobil testlardan foydalanish kerak. Fetal gemoglobin darajasining oshishi (HbF >10%) ayrim usullarda kutilganidan pastroq HbA1c natijalariga olib kelishi mumkin.
| Referens oraliq |
| |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ko'rsatmalar | Diagnostic evaluation for diabetes mellitus or prediabetes in suitable clinical contexts, Ongoing monitoring of long‑term glycemic control in diabetes, typically two to four times per year based on type of diabetes and stability of control, Reassessment after initiating or modifying antihyperglycemic therapy to reach target glucose levels, Symptoms suggestive of hyperglycemia such as polydipsia, polyuria, asthenia, visual changes, or recurrent infections |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- iron deficiency
- recent blood transfusion
Pasaygan daraja
- acute blood loss
- anemia
- chronic blood loss
- hemoglobin variants
- hemolytic anemia
- high fetal hemoglobin
- pregnancy
- sickle cell disease
Namunangiz talablari
| Namunangiz | To'liq qon |
|---|---|
| Container | Lavanda qopqoqli probirka (K3 EDTA) |
| Hajm | 4 mL (min 0.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |