Umumiy xolesterin
Kod:8012
| Kabi | Umumiy xolesterin |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kolorimetrik / fotometrik usul
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Fast for 12 hours before specimen collection
- Avoid physical exertion and emotional stress for 30 minutes prior to collection
- Do not smoke during the 30 minutes before collection
Qanday foydalanish
Umumiy xolesterin testi (qon xolesterini, total chol) yurak-qon tomir xavfini baholash, lipid profili tarkibida belgilari yo‘q shaxslarni skrining qilish va parhez o‘zgarishi hamda lipidlarni pasaytiruvchi terapiyaga javobni kuzatish uchun qo‘llanadi. Klinitsistlar odatda umumiy xolesterinni boshqa lipid ko‘rsatkichlari bilan birga qo‘llab, dislipidemiya va davolash ta’sirini to‘liqroq baholaydilar.
Cheklovlar
Xolesterin hujayra membranalari tarkibining asosiy komponenti bo‘lib, steroid gormonlar va o‘t kislotalari uchun prekursor vazifasini bajaradi. Suvda erimaganligi sababli u zichligi va tarkibiga ko‘ra farqlanuvchi lipoproteinlar tarkibida aylanadi; asosan juda past zichlikdagi lipoproteinlar (VLDL), past zichlikdagi lipoproteinlar (LDL) va yuqori zichlikdagi lipoproteinlar (HDL). LDL‑C va VLDL‑C aterogen hisoblanadi, HDL‑C esa teskari xolesterin tashuvda ishtirok etadi. Umumiy xolesterin barcha lipoprotein sinflaridagi xolesterinning yig‘indi miqdorini ifodalaydi. Aylanuvchi xolesterinning katta qismi jigar tomonidan sintez qilinadi; qo‘shimcha hissa ovqatlanishdan, xususan go‘sht va to‘liq yog‘li sut mahsulotlaridan keladi. Genetik moyillik va/yoki ratsionda ortiqcha iste’mol mavjud bo‘lganda, plazma xolesterini oshishi mumkin, bu aterosklerotik blyashka rivojlanishini, tomirlar qattiqlashishini va ishemik yurak kasalligi hamda insult xavfining ortishini rag‘batlantiradi.
| O'lchov birligi | mg/dL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Routine adult lipid screening starting at age 20, with testing at least every 5 years, Use within a lipid panel that includes LDL‑C, VLDL‑C, HDL‑C, triglycerides, and an atherogenic index, Tracking the effect of diet modification or lipid‑lowering pharmacotherapy, Cardiovascular risk appraisal when risk factors are present (tobacco use; men >45 years or women >55 years; hypertension ≥140/90 mm Hg; family history of premature atherosclerotic cardiovascular disease; coronary artery disease; prior myocardial infarction or stroke; diabetes mellitus; overweight/obesity; alcohol misuse; high intake of animal fats; low physical activity), Targeted screening in children 2–10 years with a family history of premature cardiovascular disease or hypercholesterolemia |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- anabolic steroids
- androgens
- corticosteroids
- high intake of animal fats
- pregnancy
- prolonged fasting
- smoking
- upright posture at phlebotomy
Pasaygan daraja
- allopurinol
- cholestyramine
- clofibrate
- colchicine
- diet high in polyunsaturated fatty acids
- erythromycin
- estrogens
- intense physical exercise
- supine posture at phlebotomy
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.5 mL (min 0.2 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |