Tireoglobulin, keng qamrovli (anti-Tg skriningi va RIAga refleks bilan) (Endokrin fanlar)
Kod:9007|CPT:84432, 86800|LOINC:8098-6, 3013-0
| Kabi | Anti-tireoglobulin antitanalar Tireoglobulin (ICMA) Tireoglobulin (TG-RIA) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunokimyoluminometrik analiz (ICMA)
- Radioimmunologik analiz (RIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Tireoglobulin, keng qamrovli (anti-Tg skriningi va RIAga refleks bilan) testi differensiyalangan qalqonsimon bez karsinomasida operatsiyadan keyingi kuzatuv uchun qo‘llanadi; bunda autoantitana interferensiyasini kamaytirish maqsadida anti-Tg holatiga muvofiq Tg o‘lchash usuli tanlanadi. Anti-Tg skriningi Tg immunoanalizidagi potentsial og‘ishlarni ko‘rsatadi; ijobiy natija Tg ni RIA orqali refleks qilishni ishga tushiradi, manfiy natija esa Tg ni ICMA bilan o‘lchashga imkon beradi. Anti-tireoglobulin antitanalarini (Tg Ab; anti-tireoglobulin avtoantitanalar) aniqlash autoimmun qalqonsimon bez kasalligini baholashga yordam beradi va tizimli autoimmunitetli bemorlarda qalqonsimon bezning jalb etilganligini baholashga axborot beradi.
Cheklovlar
Tireoglobulin qalqonsimon bez follikulyar hujayralaridan hosil bo‘ladigan, triyodtironin (T3) va tiroksin (T4) uchun glikoprotein-prekursordir va bez kolloidida saqlanadi. Iz miqdorlari qon aylanishiga tushadi va avtoantigen sifatida harakat qilishi mumkin, bu anti-tireoglobulin avtoantitanalarini (anti-Tg) induktsiya qiladi; ular qalqonsimon bez yallig‘lanishi va disfunksiyasiga hissa qo‘shishi mumkin. Anti-Tg antitanalari surunkali autoimmun tireoiditli shaxslarning taxminan 40% dan 70% gachaida, gipotireozli bemorlarning taxminan 70% ida, Graves kasalligiga chalinganlarning taxminan 40% ida va boshqa autoimmun holatlarga ega bemorlarning kichikroq ulushida aniqlanadi; past titrli reaktivlik sog‘lom shaxslarda, ayniqsa yoshi katta ayollarda ham kuzatilishi mumkin. Anti-Tg orbital biriktiruvchi to‘qima komponentlari bilan kross-reaksiya qilishi mumkin va tiroid-assotsiatsiyalashgan oftalmopatiya patofiziologiyasida ishtirok etishi ta’riflangan. Onada autoimmun qalqonsimon bez kasalligi bilan murakkablashgan homiladorliklarda, homiladorlik boshida va yakuniga yaqin qalqonsimon bezga qarshi avtoantitanalarni tekshirish yangi tug‘ilgan chaqaloqda qalqonsimon bez disfunksiyasi xavfini baholashga yordam berishi mumkin.
| O'lchov birligi | ng/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Surveillance after surgery for differentiated thyroid carcinoma with reflex thyroglobulin testing based on anti-Tg status, Evaluation of goiter or structural thyroid changes when accompanied by thyrotoxic features such as ophthalmopathy, weight loss, or tachycardia, Workup of systemic autoimmune disorders when thyroid autoimmunity is a concern, Assessment of female reproductive issues suspected to be linked to autoimmune thyroid disease |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- oral contraceptives
Pasaygan daraja
- antibodies to non-thyroglobulin antigens
- intrathyroidal antibody production
- thyroglobulin-antibody immune complexes
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 5 mL (min 1.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Cooper DS, Doherty GM, Haugen BR, The American Thyroid Association Guideline Taskforce, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006;16(2):109-142. PubMed 16420177
Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(4):1433-1441. PubMed 12679418
National Academy for Clinical Biochemistry. Laboratory Support for the Diagnosis of Thyroid Disease. Vol 13. 2002:48-49.
Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2005;90(10):5566-5575. PubMed 15985472