Angiotenzin II
Kod:9046|CPT:82163|LOINC:1860-6
| Kabi | Angiotenzin II |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Radioimmunologik analiz (RIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Obtain the required collection kit from the LabCorp supply department.
- No specific patient preparation is necessary.
Qanday foydalanish
Angiotenzin II (plazmadagi Ang II) testi gipertenziya, natriy yoki suyuqlik muvozanatidagi buzilishlar va yurak yetishmovchiligi bo‘yicha tekshiruv jarayonida renin–angiotenzin–aldosteron tizimi faolligini baholash uchun qo‘llanadi. O‘lchash, shuningdek, surunkali yurak yetishmovchiligiga chalingan ayrim bemorlarda angiotenzin‑konvertlovchi ferment ingibitorlari bilan davolanishga qaramay angiotenzin II faolligi saqlanib qolishi (ACE escape) holatini baholashga yordam berishi mumkin.
Cheklovlar
Renin angiotenzinogendan angiotenzin I ni ajratib oladi, angiotenzin‑konvertlovchi ferment esa uni angiotenzin II ga aylantiradi. Angiotenzin II kuchli vazokonstriktor ta’sir ko‘rsatadi, aldosteron sekretsiyasini kuchaytiradi va buyraklarda natriyning qayta so‘rilishini oshiradi; natijada ekstrasellyulyar hajm kengayadi va arterial bosim ortadi. Shuning uchun, qon aylanishidagi angiotenzin II renin–angiotenzin–aldosteron tizimining distal bosqichdagi faolligini aks ettiradi. Yurak yetishmovchiligida neyrogormonal tizimlar, jumladan renin–angiotenzin–aldosteron kaskadi, surunkali faollashgan holda qolishi mumkin. Ba’zi bemorlarda angiotenzin‑konvertlovchi ferment ingibitorlari bilan davolash paytida ham angiotenzin II faolligi saqlanib qoladi; bu hodisa ACE escape deb ataladi. Ushbu kontekstlarda plazmadagi angiotenzin II ni o‘lchash davom etayotgan renin–angiotenzin faolligini hujjatlashtirishi va klinik baholashni to‘ldirishi mumkin.
| O'lchov birligi | pg/mL |
|---|---|
| Referens oraliq | — |
| Ko'rsatmalar | Evaluation of hypertension when renin–angiotensin–aldosterone system involvement is suspected., Assessment of unexplained disturbances in sodium handling or fluid status., Characterization of neurohormonal activation in patients with heart failure., Investigation of possible ACE escape in chronic heart failure during ACE‑inhibitor treatment. |
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 3 mL (min 1.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Kuznetsova T et al. Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Projecton Genes in Hypertension. J Hypertens. 2006 Feb;24(2):235-42. [PMID: 16508563]
Yamada, T., Horiuchi, M., Dzau, V. J. Angiotensin II type 2 receptor mediates programmed cell death. Proc. Nat. Acad. Sci. 93: 156-160, 1996. [PMID: 8552595]