Inson xorionik gonadotropini, erkin beta-subbirligi
Kod:9051
| Kabi | Inson xorionik gonadotropinining erkin beta-subbirligi (beta-hCG) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kimyoluminessent immunoanaliz (CLIA)
- Ferment immunoanalizi (EIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not smoke for at least 30 minutes before the blood draw.
Qanday foydalanish
Inson xorionik gonadotropinining erkin beta-subbirligi bo‘yicha tekshiruv (erkin beta-hCG; hCG, erkin beta-subbirligi) birinchi va ikkinchi trimestrlarda ona skriningiga homila xromosomal aneuploidiyasi xavfini baholash maqsadida kiritiladi. Natijalar gestatsion trofoblastik kasallikni tashxislash va monitoring qilish hamda davolashga javobni baholash uchun qo‘llanadi. O‘sma markeri sifatida erkin beta-hCG moyakning germinogen o‘smalarini baholash va ularni uzoq muddatli kuzatishda qo‘llab-quvvatlaydi hamda trofoblastik bo‘lmagan malign neoplaziyalar tomonidan hCG ning ektopik ishlab chiqarilishini aniqlashga yordam beradi.
Cheklovlar
Inson xorionik gonadotropini (hCG) 37.5 kDa glikoprotein bo‘lib, umumiy alfa zanjir va gormon-spetsifik beta zanjirdan tashkil topgan. Alfa subbirligi lyuteinlashtiruvchi gormon, follikulani stimullovchi gormon va qalqonsimon bezni stimullovchi gormon bilan umumiy bo‘lib, beta subbirligi biologik spetsifiklikni ta’minlaydi. Homiladorlik davrida sintez asosan sinsitiotrofoblastda amalga oshadi, past darajada gipofizda ham ishlab chiqarilishi mavjud; qon aylanishidagi hCG ning katta qismi jigarda metabolizatsiyalanadi, taxminan 20% si siydik bilan chiqariladi. Homiladorlikning erta davrida (taxminan 2–5-haftalar) qon aylanishidagi erkin beta-hCG tez ko‘tariladi va ko‘p homilalikda nisbatan yuqoriroq bo‘lishi mumkin; 10–11-haftalar atrofida cho‘qqiga chiqadi va keyin pasayadi. Erkin beta-subbirlikni o‘lchash birinchi va ikkinchi trimestr aneuploidiya skrining algoritmlarining tarkibiy qismidir: birinchi trimestrda ona qon zardobidagi yuqori konsentratsiyalar trisomiya 21 xavfi bilan bog‘liq, past konsentratsiyalar esa trisomiya 18 da kuzatilishi mumkin. Erkin beta-hCG gestatsion trofoblastik kasallikni (masalan, gidatidiform mola, xoriokarsinoma) tashxislash va monitoring qilishda ham yordam beradi hamda hCG ni ektopik ishlab chiqaradigan moyak germinogen o‘smalarida va ayrim trofoblastik bo‘lmagan saratonlarda oshishi mumkin; davolashga javobni kuzatish uchun ketma-ket o‘lchovlar qo‘llanadi.
| O'lchov birligi | ng/mL |
|---|---|
| Referens oraliq | — |
| Ko'rsatmalar | Maternal screening in the first and second trimesters to estimate the risk of fetal chromosomal aneuploidy, Workup and serial monitoring of gestational trophoblastic disease, Assessment when a testicular germ cell tumor is suspected, Use within integrated prenatal screening strategies that inform risk assessment for fetal malformations |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- nontrophoblastic malignancy producing hcg
- testicular tumors
- trophoblastic disease
Pasaygan daraja
- antineoplastic therapy
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Saqlash tayyorlik | Sovutilgan, Muzlatilgan |
References
Woldemariam GA, Butch AW. Immunoextraction-tandem mass spectrometry method for measuring intact human chorionic gonadotropin, free β-subunit, and β-subunit core fragment in urine. Clin Chem. 2014;60(8):1089-1097.
Chambers AE, Mills WE, Mercadé I, Crovetto F, Crispi F, Bodi LR, Pugia M, Mira A, Lasalvia L, Banerjee S, Casals E, Gratacos E. The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy. BMC Pregnancy Childbirth. 2014;14:197.
Toriola AT, Tolockiene E, Schock H, Surcel HM, Zeleniuch-Jacquotte A, Wadell G, Toniolo P, Lundin E, Grankvist K, Lukanova A. Free β-human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer. Future Oncol. 2014;10(3):377-384.
Долгов В.В., Меньшиков В.В. Клиническая лабораторная диагностика: национальное руководство. Том I. Москва: ГЭОТАР-Медиа; 2012.