Qaytarish

Kardiolipin antitanalari, IgG va IgM

Kod:16019

Sinonimlar
Антикардиолипиновые антителаАКЛaCL antibodyanticardiolipin antibodiesantiphospholipid antibodiesAPAscardiolipin antibodies
KabiKardiolipinga qarshi antitana, IgG Kardiolipinga qarshi antitana, IgM

Tahlil ma'lumotlari

Tadqiqot usuli

  • Kimyoluminessent immunoanaliz (CLIA)

Kutilayotgan natija topshirish vaqti

1 kun

Maxsus tayyorlik

  • Avoid smoking for 30 minutes before the blood draw.

Qanday foydalanish

Kardiolipin antitanalari, IgG va IgM (antikardiolipin antitanalari; aCL) tekshiruvi antifosfolipid sindromi (AFS) tashxisi va tasnifini qo‘llab-quvvatlaydi. Natijalar gumon qilingan yoki tasdiqlangan AFS bo‘lgan bemorlarda, venoz hamda arterial hodisalarni qamrab olgan holda, trombotik xavfni baholashga hissa qo‘shadi. Ushbu analiz ko‘pincha boshqa antifosfolipid antitana tadqiqotlari, jumladan lupus antikoagulyanti va beta-2 glikoprotein I ga qarshi antitanalar bilan birga talqin qilinadi; bu klinik xavfni aniqroq baholash va boshqaruv qarorlarini yo‘naltirishga yordam beradi.

Cheklovlar

Antikardiolipin antitanalar (aCL) kardiolipin va beta-2 glikoprotein I komplekslarini taniydi va antifosfolipid antitanalar spektrining bir qismidir; ushbu spektrga lupus antikoagulyanti va beta-2 glikoprotein I ga qarshi antitanalar ham kiradi. Ularning mavjudligi venoz va arterial tromboz hamda antifosfolipid sindromiga (AFS) xos homiladorlikdagi morbidlik bilan bog‘liq. Tekshiruvni o‘tkir trombotik epizoddan tashqarida o‘tkazish ma’qul, chunki o‘tkinchi aCL reaktivligi kuzatilishi mumkin; AFS tasnifi uchun doimiylik 12 haftadan so‘ng takroriy test bilan ko‘rsatilishi lozim. aCL analizlari nisbatan yuqori analitik sezgirlikka ega bo‘lsa-da, klinik spetsifiklik cheklangan, va past titrli yoki qisqa muddatli pozitivlik infeksiyalar va boshqa holatlar bilan birga kechishi mumkin. AFS tasnifi mos klinik namoyonlar bilan birga doimiy laborator ijobiylikni talab qiladi; ko‘pincha bu lupus antikoagulyanti va beta-2 glikoprotein I ga qarshi natijalar bilan mos keladi; uchala markerning bir vaqtda ijobiy bo‘lishi yuqoriroq trombotik xavf bilan korrelyatsiya qiladi. AFS tasdiqlangach, klinik holat o‘zgarmagan bo‘lsa, aCL ni muntazam ketma-ket o‘lchash tavsiya etilmaydi. Revmatoyd faktor IgM aCL qiymatlarini soxta ravishda oshirishi mumkin va talqinda inobatga olinishi zarur. Biologik yolg‘on-musbat nodtreponemal sifilis testlari (masalan, RPR) ushbu testlar kardiolipin saqlovchi antigenlardan foydalangani sababli yuzaga kelishi mumkin va ularni maxsus antitana testlari bilan keyingi tekshiruv bilan baholash talab etiladi.

Referens oraliq
MinMaks
015
Ko'rsatmalarUnprovoked or suspected venous or arterial thrombosis occurring before age 50 years, or thrombosis in an atypical vascular location., Workup of recurrent pregnancy loss defined as three or more consecutive miscarriages before 22 weeks’ gestation., Clinical features raising concern for antiphospholipid syndrome: valvular heart disease with vegetations, leaflet thickening, or dysfunction; livedo reticularis; nephropathy; thrombocytopenia; preeclampsia; chorea; or epilepsy., Thrombosis or pregnancy loss in the context of an autoimmune disorder (e.g., systemic lupus erythematosus)., Evaluation of a prolonged activated partial thromboplastin time in conjunction with lupus anticoagulant testing., Reactive nontreponemal syphilis screen (e.g., RPR) requiring assessment for a potential biologic false-positive result.

Natija og'ishlarining mumkin sabablari

Oshgan daraja

  • herpes zoster infection
  • hiv infection
  • rheumatoid factor
  • viral hepatitis

Namunangiz talablari

NamunangizZardob
ContainerOltin/yo'lbars qopqoqli probirka (SST, gel ajratgich)

References

Devreese K, Hoylaerts MF. Challenges in the diagnosis of the antiphospholipid syndrome. Clin Chem. 2010 Jun;56(6):930-40.

Ortel TL. Antiphospholipid syndrome: laboratory testing and diagnostic strategies. Am J Hematol. 2012 May;87 Suppl 1:S75-81.

Lakos G, Favaloro EJ, Harris EN, Meroni PL, Tincani A, Wong RC, Pierangeli SS. International consensus guidelines on anticardiolipin testing: report from the 13th International Congress on Antiphospholipid Antibodies. Arthritis Rheum. 2012 Jan;64(1):1–10.

Chernecky CC, Berger BJ. Laboratory Tests and Diagnostic Procedures. 5th ed. Saunders Elsevier; 2008.