To‘qima transglutaminazaga (tTG) qarshi antitanachalar, IgG
Kod:16023|CPT:86364|LOINC:32998-7
| Kabi | To‘qima transglutaminaza (tTG) IgG |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment immunoanalizi (EIA)
- Kimyoluminessent immunoanaliz (CLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Avoid smoking during the 30 minutes preceding the blood draw.
Qanday foydalanish
To‘qima transglutaminazaga (tTG) qarshi IgG testi (anti‑tTG IgG; tTGA) seliak kasalligi/glutenga sezgir enteropatiyani skrining qilish, tashxisni tasdiqlash va monitoring qilish uchun qo‘llanadi, ayniqsa selektiv IgA tanqisligi bo‘lgan shaxslarda. U dermatitis herpetiformis bo‘yicha diagnostik ishlarni qo‘llab‑quvvatlaydi va davolangan seliak kasalligida glutensiz parhezga rioya qilinishini hamda javobni baholash uchun qo‘llanadi.
Cheklovlar
To‘qima transglutaminaza seliak kasalligida ustun avtoantigen bo‘lib, endotelial hujayralar, gepatositlar, eritrotsitlar hamda ingichka ichak epiteliysi va shilliq osti qavatida mavjud. Genetik moyilligi bo‘lgan, ko‘pincha HLA‑DQ2/DQ8 ni tashuvchi shaxslarda, tTG tomonidan oziq‑ovqat gliadini fermentativ deamidatsiyasi peptidlarning immunogenligini oshiradi, shilliq qavat yallig‘lanishini, villus atrofiyasini va natijada malabsorbtsiyani rag‘batlantiradi. Seliak kasalligida avtoimmun javob gliadin, endomisiy va to‘qima transglutaminazaga qarshi antitanachalarni o‘z ichiga oladi. Ular orasida anti‑tTG seliak kasalligi uchun yuqori analitik sezgirlik va xoslik ko‘rsatadi. Selektiv IgA tanqisligi seliak kasalligi bo‘lgan bemorlarda ko‘proq uchraydi; bunday sharoitda IgA‑ga asoslangan serologiya soxta‑manfiy natijalar berishi mumkin. Shuning uchun tTG IgG ni o‘lchash IgA tanqisligiga shubha qilinganda afzal serologik yondashuv hisoblanadi va u umumiy zardob IgA bilan birga talqin qilinishi lozim. Antitanacha titrlari odatda kasallik faolligini aks ettiradi va glutensiz parhezga barqaror rioya qilinganda pasayadi. Manfiy tTG IgG natijasi seliak kasalligini istisno etmaydi; natijalar klinik topilmalar va boshqa serologik testlar bilan birgalikda talqin qilinishi zarur.
| Referens oraliq |
| ||||
|---|---|---|---|---|---|
| Ko'rsatmalar | Workup of suspected celiac disease presenting with chronic diarrhea, recurrent vomiting, abdominal pain, pediatric growth failure, or iron‑deficiency anemia, Skin eruption consistent with dermatitis herpetiformis, Seizure disorder or peripheral neuropathy when malabsorption is suspected, Atopic dermatitis or recurrent oral aphthae/cheilitis with features suggestive of celiac disease, Clinical evidence of vitamin or nutrient deficiency (eg, osteopenia, tetany, bleeding tendency) or reproductive manifestations including menstrual irregularity or amenorrhea, infertility, or erectile dysfunction, First‑degree family history of celiac disease or other celiac disease risk factors, Known or suspected selective IgA deficiency, Follow‑up of confirmed celiac disease to monitor response to a gluten‑free diet |
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.5 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul;3(7):797-801. PubMed 9212111
Volta U, Molinaro N, De Franchis R, et al. Correlation between IgA antiendomysial antibodies and subtotal villous atrophy in dermatitis herpetiformis. J Clin Gastroenterol. 1992 Jun;14(4):298-301. PubMed 1607605
Dahlbom I, Olsson M, Forooz NK, Sjöholm AG, Truedsson L, Hansson T. Immunoglobulin G (IgG) anti-tissue transglutaminase antibodies used as markers for IgA-deficient celiac disease patients. Clin Diagn Lab Immunol. 2005 Feb;12(2):254-8.
Volta U, Villanacci V. Celiac disease: diagnostic criteria in progress. Cell Mol Immunol. 2011 Mar;8(2):96-102.
Armstrong D, Don-Wauchope AC, Verdu EF. Testing for gluten-related disorders in clinical practice: the role of serology in managing the spectrum of gluten sensitivity. Can J Gastroenterol. 2011 Apr;25(4):193-7.
Fauci AS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 17th ed. New York, NY: McGraw-Hill; 2008.