Albumin/Kreatinin nisbati, tasodifiy siydik
Kod:7016|CPT:82043, 82570|LOINC:2161-8, 14957-5, 9318-7
| Kabi | Kreatinin, siydik Albumin, siydik Albumin/Kreatinin nisbati |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunoturbidimetriya
- Kinetik usul
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not consume alcohol for 24 hours before collecting the urine sample.
- Only with clinician approval, hold diuretics for 48 hours prior to urine collection.
Qanday foydalanish
Albumin/Kreatinin nisbati, tasodifiy siydik (ACR) tasodifiy namunada siydik albuminini miqdoriy baholash va uni kreatininga nisbatan ifodalash orqali mikroalbuminuriyani aniqlash va kuzatish uchun qo‘llaniladi. Ushbu analiz diabetik nefropatiyaning erta diagnostikasi va uzoq muddatli kuzatuvini qo‘llab-quvvatlaydi hamda ko‘pincha “mikroalbumin” testi yoki siydik mikroalbumini o‘lchovi deb ataladi. Shuningdek, u surunkali arterial gipertenziya, kongestiv yurak yetishmovchiligi, glomerulonefrit va yallig‘lanishli yoki kistoz buyrak kasalliklari bilan bog‘liq buyrak ishtirokini baholashda ma’lumot beradi. Bundan tashqari, ACR sistemik qizil volchanka va amiloidoz kabi tizimli kasalliklarda buyrak jarayonini baholashda, shuningdek, odatiy proteinuriya yo‘qligida ham nefropatiyadan shubhalanganda homiladorlikda tekshiruvni qo‘llab-quvvatlaydi.
Cheklovlar
Mikroalbuminuriya fiziologik darajadan yuqori, ammo yaqqol proteinuriya chegarasidan past bo‘lgan siydik albomini ajralishini ifodalaydi va klinik proteinuriyadan oldin paydo bo‘ladi. U erta glomerulyar shikastlanishni aks ettiradi va mos terapiya bilan qaytishi mumkin. Albumin ajralishi kundan kunga o‘zgarib turishi sababli, tasdiqlash uchun ketma-ket o‘lchovlar zarur. 3–6 oy davomida o‘tkazilgan 3 ta o‘lchovdan kamida 2 tasi g‘ayritabiiy bo‘lishi kerak, shundan keyingina mikroalbuminuriya uchun chegara bajarilgan deb hisoblanadi.
| O'lchov birligi | ratio | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Type 2 diabetes mellitus at diagnosis, with repeat testing every 6 months, Type 1 diabetes mellitus of more than 5 years' duration, every 6 months, Pediatric type 1 diabetes mellitus with labile control, beginning 1 year after onset, Chronic or poorly controlled arterial hypertension, Congestive heart failure accompanied by edema, Pregnancy when nephropathy is suspected despite absence of routine proteinuria, Differential evaluation of early-stage glomerulonephritis, Systemic lupus erythematosus or amyloidosis to identify early renal involvement |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- congestive heart failure
- dehydration
- exercise
- fever
- high-protein diet
- infection
- marked hyperglycemia
- marked hypertension
- urinary tract infection
Pasaygan daraja
- ace inhibitors
- excessive hydration
- low-protein diet
- nsaids
Namunangiz talablari
| Namunangiz | Urina |
|---|---|
| Container | Steril siydik idishi |
| Hajm | 10 mL (min 2 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Metcalf P, Baker J, Scott A, Wild C, Scragg R, Dryson E. Albuminuria in people at least 40 years old: effect of obesity, hypertension, and hyperlipidemia. Clin Chem. 1992 Sep;38(9):1802-1808. PubMed 1526018.
Keane WF, Eknoyan G. Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): a position paper of the National Kidney Foundation. Amer. J. Kidney Dis. 2000;33:1004-1010.
Mogensen CE, Keane WF, Bennett PH, et al. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet. 2005;346:1080-1084.
Saudi J Kidney Dis Transpl. 2012 Mar;23(2):311-315. Ambulatory blood pressure monitoring in children and adolescents with type-1 diabetes mellitus and its relation to diabetic control and microalbuminuria. Basiratnia M, Abadi SF, Amirhakimi GH, Karamizadeh Z, Karamifar H.