Tireoperoksidazaga qarshi antitanachalar (Anti‑TPO) (RDL)
Kod:9008|CPT:86376|LOINC:8099-4
| Kabi | Tireoperoksidazaga qarshi antitanachalar (Anti‑TPO) (RDL) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Kimyoluminessent immunoanaliz (CLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not smoke during the 30 minutes before the blood draw.
Qanday foydalanish
Anti‑TPO (RDL) testi, shuningdek tireoperoksidaza antitanachasi (TPOAb) tahlili deb ataladi va tarixan anti‑tiroid mikrosomal antitanachalar sifatida nomlangan, autoimmun qalqonsimon bez kasalliklarini — Xashimoto tireoiditi, Grevs kasalligi, postpartum tireoidit va surunkali autoimmun tireoidit — baholashda yordam beradi. Qalqonsimon bez funksiyasini baholovchi testlar bilan birgalikda talqin qilinganda, zob yoki tireoid disfunksiyasining autoimmun sabablarini noautoimmun etiologiyalardan farqlashga ko‘maklashadi. Anti‑TPO musbatligi gipotiroidizm kontekstida Xashimoto tireoiditi tashxisini qo‘llab‑quvvatlaydi, biroq antitanachalar boshqa tireoid kasalliklarda va tizimli autoimmun kasalliklarga chalingan bemorlarda ham uchrashi mumkin. Tahlil homiladorlik davrida tireoid disfunksiyasi xavfini va anti‑TPO musbat onalardan tug‘ilgan chaqaloqlarda xavfni baholash uchun qo‘llanadi hamda autoimmun qalqonsimon bez kasalligini vaqt davomida kuzatish maqsadida takrorlanishi mumkin.
Cheklovlar
Ushbu tahlil tireoperoksidazaga yo‘naltirilgan autoantitanachalarni aniqlaydi; tireoperoksidaza — yodidning oksidlanishi, tiroglobulinning organifikatsiyasi (yodlanishi) va yodtirozinlarning qo‘shilishi orqali T4 va T3 hosil bo‘lishini katalizlaydigan apikal membrana fermentidir. Immun tolerantlikning yo‘qolishi anti‑TPO ishlab chiqilishiga va limfotsitar tireoiditga olib keladi; bu to‘qima shikastlanishi va gormon sintezi buzilishiga, odatda gipotiroidizmga, kamroq hollarda esa o‘tkinchi tireotoksik fazaga sabab bo‘ladi. Zamonaviy yuqori sezgir immunoanalizlar anti‑TPO ni Xashimoto tireoiditining taxminan 95% holatlarida va Grevs kasalligining qariyb 85% holatlarida aniqlaydi. Antitanachalar idiopatik gipotiroidizmda, tugunli tireoid kasalliklarida va qalqonsimon bez karsinomasida, shuningdek tizimli autoimmun kasalliklarga ega bemorlarda ham kuzatiladi. Onadagi anti‑TPO platsentadan o‘tadi va homila hamda yangi tug‘ilgan chaqaloqning tireoid funksiyasiga ta’sir ko‘rsatishi mumkin; shu bois homiladorlik davrida antitanacha musbatligi akusherlik va neonatologik yurituvga ta’sir ko‘rsatadi.
| O'lchov birligi | IU/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Workup of suspected autoimmune thyroid disease, including Hashimoto thyroiditis, Graves disease, or postpartum thyroiditis., Evaluation of thyroid dysfunction when TSH, free T4, or T3 results are abnormal., Ongoing monitoring of autoimmune thyroid disease to gauge disease activity and response to therapy., Preconception or obstetric assessment when pregnancy loss, preeclampsia, preterm birth, or failed assisted reproduction raises concern for thyroid autoimmunity., Assessment of neonates born to mothers who are anti‑TPO positive or have postpartum thyroiditis., Baseline and follow‑up testing in patients receiving amiodarone, lithium, interferon alfa, or interleukin‑2., Evaluation of potential thyroid involvement in systemic autoimmune diseases (eg, rheumatoid arthritis, systemic lupus erythematosus, pernicious anemia, systemic vasculitis, type 1 diabetes mellitus)., Targeted screening of individuals at increased risk for autoimmune thyroiditis, such as pregnant patients with a family history. |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- amiodarone
- interferon alfa
- interleukin-2
- lithium
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.3 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Autoimmune Thyroiditis edited by W.A. Scherbaum, U. Bogner, B. Weinheimer, G.F. Bottazzo: Springer-Verlag, Berlin, 1991.
Diseases of the Thyroid edited by Lewis E. Braverman MD. Humana Press, Totowa, N. J., 2003.
Thyroid Disease in Clinical Practice, I. Ross McDougall, Chapman and Hall, London, 1992.
Surks MI, Ortiz E, Daniels GH and others. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004; 291(2): 228-38.
Ladenson PW, Singer PA, Aink B and others. American Thyroid Association Guidelines for Detection of Thyroid Dysfunction. Arch Inten Med 2000; 160: 1573-5.
Molecular Pathology of Endocrine Diseases, Jennifer L., Hunt Springer Science+Business Media, London, 2010 г.