Steroid profili, so'lak (LC-MS/MS)
Kod:90331
| Kabi | Kortizon Kortizol Androstendion Degidroepiandrosteron Testosteron, erkin Estradiol, erkin Progesteron, erkin 17-gidroksiprogesteron |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Suyuq xromatografiya va tandem mass-spektrometriya (LC-MS/MS)
Kutilayotgan natija topshirish vaqti
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Maxsus tayyorlik
- Avoid caffeine, alcohol, and strenuous exercise for 24 hours before and throughout saliva collection.
- Do not smoke during the 60 minutes prior to collection.
- Rinse the mouth with water and wait 10 minutes before collecting the specimen.
- For 30 minutes before collection, do not eat, brush or floss teeth, use mouthwash, or chew gum.
- Consult the treating clinician about whether to pause sedatives, cortisone acetate, estrogens, oral contraceptives, or topical/systemic glucocorticoids before collection, as these agents may raise cortisol; any medication changes must be directed by the clinician.
Qanday foydalanish
Steroid profili, so'lak (LC-MS/MS)—shuningdek so'lakdagi steroid gormonlar profili yoki so'lakdagi jinsiy steroidlar paneli deb ham ataladi—adrenal va gonadal funksiyani hamda gipotalamo–gipofizar–adrenal va gipotalamo–gipofizar–gonadal o'qlar faolligini baholash uchun qo'llaniladi. Klinik qo'llanilish sohalariga balog'atga yetish jarayonining buzilishlarini (erta boshlanish yoki kechikish) baholash; ayollarda hayz ko'rishning buzilishi, anormal bachadon qon ketishi, bepushtlik va homiladorlik asoratlari kabi reproduktiv muammolar; erkaklarda ginekomastiya, erektil disfunktsiya va bepushtlik kiradi. Panel steroid gormonlar terapiyasini monitoring qilishga, yordamchi reproduktiv texnologiyalar sikllari davomida gormonal baholashga va endokrin etiologiya gumon qilinganda metabolik yoki suv-elektrolit buzilishlarini tekshirishga yordam beradi. So'lakdagi kortizol va kortizonni o'lchash sutkalik variatsiyani baholashni osonlashtiradi.
Cheklovlar
Kortikosteroidlar va gonadal steroidlarni o'z ichiga olgan steroid gormonlar xolesterindan sintezlanadi va metabolizm, tomir tonusi, reproduktiv funksiyalar va stress javobini tartibga solish uchun lipidga eruvchi mexanizmlar orqali ta'sir ko'rsatadi. Biosintetik yo'llar o'zaro bog'langanligi sababli, diagnostik baholash ko'pincha bitta analitni o'lchashdan ko'ra bir nechta steroidlarni birgalikda o'lchaganda ko'proq ma'lumot beradi. Ushbu so'lak steroid profili erkin kortizol va kortizonni; androgenlar (androstendion, degidroepiandrosteron va erkin testosteron); estrogenlar (erkin estradiol); progestogenlar (erkin progesteron); hamda 17-gidroksiprogesteronni miqdoriy baholaydi va buyrakusti hamda gonadal steroidogenezning integrallashgan manzarasini taqdim etadi. So'lakdagi kortizol va kortizon sirkadiyal ritmga bo'ysunadi; bu holat talqin etishda inobatga olinishi lozim. LC-MS/MS usuli xromatografik ajratish va alohida steroidlarning massa-selektiv aniqlashi kombinatsiyasi orqali yuqori analitik spetsifiklikka erishadi.
| Referens oraliq |
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|---|---|---|---|---|---|
| Ko'rsatmalar | Workup of female reproductive concerns, including irregular menses, abnormal uterine bleeding, infertility, or pregnancy complications, Assessment of male reproductive issues such as gynecomastia, erectile dysfunction, or infertility, Evaluation of abnormal pubertal timing, including early onset or delayed progression, Hormone profiling during assisted reproductive technology cycles, Assessment of menopausal vasomotor symptoms accompanied by mood changes, insomnia, or atypical bleeding, Investigation of metabolic or water–electrolyte disturbances when an endocrine cause is considered |
Namunangiz talablari
| Namunangiz | So'lak |
|---|---|
| Container | Steril so'lak yig'ish probirkasi |
References
Bravo EL. Physiology of the adrenal cortex. Urol Clin North Am. 1989 Aug;16(3):433-437. PubMed 2665269.
Kirkman S, Nelson DH. Alcohol-induced pseudo-Cushing's disease: A study of prevalence with review of the literature. Metabolism. 1988 Apr;37(4):390-394. PubMed 2833680.
Koal T, Schmiederer D, Pham-Tuan H, Röhring C, Rauh M. Standardized LC-MS/MS based steroid. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):129-38.
Soldin SJ, Soldin OP. Steroid hormone analysis by tandem mass spectrometry. Clin Chem. 2009 Jun;55(6):1061-6.
Vieira JG, Nakamura OH, Carvalho VM. Determination of cortisol and cortisone in human saliva by a liquid chromatography-tandem mass spectrometry method. Arq Bras Endocrinol Metabol. 2014 Nov;58(8):844-50.
Zhang K, Fent K. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Sci Total Environ. 2018 Jan 1;610-611:1164-1172.