Mycoplasma hominis Antibody, IgG, Titer

The Mycoplasma hominis Antibody, IgG, Titer (also reported as anti-Mycoplasma hominis IgG or M. hominis–specific IgG) is used to substantiate recent or past infection. It supports the diagnostic workup of urogenital syndromes where alternative etiologies, such as Chlamydia trachomatis or Trichomonas vaginalis, are considered. It is also applied when chronic inflammatory disease of the urogenital tract is suspected and as part of preconception assessment to exclude M. hominis infection.

Mycoplasma hominis colonizes genital mucosa and can behave as an opportunistic pathogen within the urogenital tract. Transmission is usually sexual, and coinfection with other organisms is common, including Neisseria gonorrhoeae, Ureaplasma species, Trichomonas vaginalis, and Chlamydia trachomatis. Vertical transmission may occur during pregnancy or at delivery, and neonatal presentations can include meningitis, respiratory infection, or sepsis. Following infection, the humoral response involves IgA, IgM, and IgG. Production of IgG generally begins 2–4 weeks after exposure and can persist for prolonged intervals, particularly when infection is chronic. Detection of M. hominis–specific IgG provides evidence of prior or ongoing exposure and may align with continuing inflammatory disease in the urogenital tract.