Mycoplasma genitalium, NAA, Swab

The Mycoplasma genitalium, NAA, Swab test (also referred to as M. genitalium DNA NAAT or PCR) detects Mycoplasma genitalium DNA in urogenital specimens for the diagnosis of sexually transmitted infection. It assists in evaluating nongonococcal urethritis, cervicitis, and pelvic inflammatory disease, and in differential workups performed alongside testing for Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma species. The assay may also be applied to document microbiologic response following antimicrobial treatment and for targeted screening of selected risk groups.

Mycoplasma genitalium is a pathogenic mycoplasma that attaches to urogenital epithelial surfaces and is transmitted predominantly through sexual contact; vertical transmission can occur during pregnancy or delivery. Infection is often asymptomatic. In men, it is associated with nongonococcal urethritis. In women, reported manifestations include urethritis, cervicitis, vaginitis, endometritis, adnexitis, and pelvic inflammatory disease. Coinfection is common with Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Ureaplasma spp. Laboratory detection relies on nucleic acid amplification techniques, typically real-time PCR, that target organism-specific DNA sequences. Such assays provide analytic sensitivity suited to low organism burden in urogenital specimens and are preferred for diagnosing M. genitalium infection.