Vitamin E (alfa va gamma tokoferol)
Kod:12014|CPT:84446|LOINC:1823-4, 63370-1
| Kabi | Vitamin E (alfa-tokoferol) Vitamin E (gamma-tokoferol) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Suyuq xromatografiya va tandem mass-spektrometriya (LC-MS/MS)
- Yuqori samarali suyuq xromatografiya va mass-spektrometriya (HPLC-MS)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Do not eat for 2–3 hours before the blood draw; water is allowed.
- Avoid smoking during the 30 minutes before specimen collection.
- Discuss with the clinician whether to temporarily stop vitamin E or multivitamin supplements before testing.
Qanday foydalanish
Vitamin E (alfa va gamma tokoferol) tahlili vitamin E yetishmovchiligini tasdiqlash yoki istisno etish uchun, masalan, muddatidan oldin tug‘ilganlarda gemolitik kasallik va chaqaloqlarda neyromuskulyar kasalliklar yoki xolestazi bo‘lgan kattalarda qo‘llaniladi. Shuningdek, uzoq muddatli parenteral oziqlantirishda saqlanayotgan bemorlarni baholashda va malign neoplaziya yoki malabsorbsiya, jumladan kistoz fibroz, hamda ichak bypass operatsiyasidan keyingi holatdagi shaxslarni baholashda qo‘llaniladi. Alfa‑tokoferol va gamma‑tokoferol (tokoferol; alfa‑tokoferol) o‘lchovi brown-bowel sindromini tekshirishda va trombotsitopatiya yoki koagulopatiya gumon qilinganda yuqori doza qo‘shimchalar natijasidagi ortiqcha miqdorni hujjatlashtirishda yordam beradi. Konsentratsiyalar xolestatik jigar va o‘t yo‘llari kasalliklari hamda yog‘ malabsorbsiya kabi yetishmovchilikka olib keladigan buzilishlar og‘irligini baholashga xizmat qiladi va hipovitaminoz E asoratlarini oldini olishga qaratilgan choralarni qo‘llab-quvvatlaydi.
Cheklovlar
Vitamin E sakkizta molekuladan iborat guruhni anglatadi — to‘rtta tokoferol va to‘rtta tokotrienol, shu jumladan esterifikatsiyalangan shakllar. U ratsiondan olinadi, ichakdan so‘rilishi uchun safro talab etiladi, xilomikronlar tarkibida qon aylanishiga kiradi va keyinchalik past zichlikdagi lipoproteinlar tomonidan tashiladi. To‘qimalar bo‘ylab taqsimlanishi keng, yuqori konsentratsiyalar yog‘ to‘qimasi, jigar, mushak va asab tizimida kuzatiladi. Alfa‑tokoferol asosiy lipid-faza antioksidanti bo‘lib, hujayra membranalari, oqsillar va nuklein kislotalarga oksidativ shikastlanishni cheklaydi hamda immun funksiyaga, reproduktiv salomatlikka, ko‘rish qobiliyatiga va normal gemostazga hissa qo‘shadi. Yetishmovchilik odatda ichakda yog‘larning so‘rilishining buzilishi yoki xolestazdan (masalan, kistoz fibroz yoki xolestatik jigar kasalligi), lipoprotein assambleyasining irsiy nuqsonlaridan (masalan, abetalipoproteinemiya) yoki muddatidan oldin tug‘ilish/past tug‘ilish vaznidan kelib chiqadi. Klinik belgilarga miopatiya, spinoserebellar ataksiya, periferik neyropatiya va gemoliz kiradi. Ortiqcha qabul qilish — ko‘pincha vitamin E yoki multivitaminlar kabi qo‘shimchalar sabab — A va K vitaminlariga antagonistik ta’sir ko‘rsatishi mumkin va trombotsitopatiya, koagulopatiya, qorong‘uga moslashishning buzilishi hamda gipoglikemiya bilan bog‘liq. Vitamin E organizmda to‘planadi.
| O'lchov birligi | mg/L | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Assessment of unexplained myopathy, ataxia, or peripheral neuropathy when vitamin E deficiency is suspected, Evaluation of fat‑malabsorption syndromes, including pancreatic insufficiency or after gastric resection/bariatric surgery, Chronic cholecystitis accompanied by impaired fat absorption, Long‑standing liver or biliary tract disease with reduced absorption of fats and fat‑soluble vitamins, Hemolytic anemia potentially related to vitamin E deficiency, Nutritional assessment in individuals with restrictive diets or low dietary vitamin E intake |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- multivitamin use
- vitamin e supplementation
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.8 mL (min 0.4 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Ageeva EV, Stepanova OI. Role of vitamin E in the prevention of cardiovascular diseases. Kardiologiia. 2018;58(3):75-82.
Belyaeva NF, Krylov AA. Vitamin E: Biochemical Aspects and Clinical Application. Moscow: Meditsina; 2015. 240 p.
Vasiliev AV. Effect of vitamin E on reproductive function. Akusherstvo i Ginekologiia. 2019;(4):60-65.
Gromova OA, Torshin II. Vitamin E in neurological practice. Nevrologiia, Neiropsikhiatriia, Psikhosomatika. 2017;9(2):88-95.
Dmitrieva MV. Vitamin E and its role in the antioxidant defense of the body. Biomeditsinskaia Khimiia. 2020;66(1):35-42.