Mioglobin
Kod:13002|CPT:83874|LOINC:2639-3
| Kabi | Mioglobin, qon zardobi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Elektrokimyoluminessent immunoanaliz (ECLIA)
- Immunoturbidimetriya
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- If taking high‑dose biotin (vitamin B7/B8, vitamin H, coenzyme R), discontinue for at least 72 hours before the blood draw.
- For infants younger than 1 year, withhold feeding for 30–40 minutes prior to collection.
- Do not eat for 2–3 hours before collection; water is allowed.
- Avoid vigorous exercise and minimize emotional stress for 30 minutes before collection.
- Do not smoke during the 30 minutes preceding collection.
Qanday foydalanish
Qon zardobida mioglobin testi o'tkir va subo'tkir mushak shikastlanishini baholash uchun qo'llanadi, jumladan miokard nekrozini erta aniqlash va rabdomiolizning diagnostik tekshiruvini o'tkazish. Mioglobin odatda o'tkir miokard infarktida bir necha soat ichida aniqlanadigan darajaga yetadi va infarkt hajmi bilan korrelyatsiya qilishi mumkin; biroq yurakka xoslikning cheklanganligi tufayli natijalar elektrokardiografik ma'lumotlar va yurak troponini bilan birga talqin qilinadi. Yuqori konsentratsiyalar travma, ishemiya, malign gipertermiya, kuchli jismoniy zo'riqish, yallig'lanishli miopatiyalar va mushak distrofiyalarida ham kuzatiladi. Ketma-ket o'lchovlar mushak shikastlanishi kechishini kuzatishda yordam beradi. Klinik amaliyotda qo'llaniladigan sinonimlar: mioglobinemiya va zardob mioglobini.
Cheklovlar
Mioglobin skelet va yurak mushagida joylashadi va hujayra ichidagi kislorod zahirasi vazifasini bajaradi. Normal sharoitda aylanmadagi darajalari juda past; miyosit nekrozi paytida konsentratsiya tez ko'tariladi. O'tkir miokard infarktida mioglobin 1–2 soat ichida oshadi va nisbatan tezda boshlang'ich darajaga qaytadi. Marker yurak shikastlanishiga xos emas va mushak ichiga in'yeksiyalardan so'ng, yuqori kuchlanishli elektr shikastlanishida hamda turli skelet mushak kasalliklarida oshishi mumkin. Mioglobin buyrak filtratsiyasi orqali chiqariladi; massiv mushak shikastlanishiga hamroh bo'ladigan keskin yuqori ko'tarilishlar o'tkir buyrak shikastlanishiga hissa qo'shishi mumkin.
| O'lchov birligi | ng/mL | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Evaluation of suspected acute myocardial infarction as an early marker: concentrations rise within 1–3 hours and peak by 8–12 hours., Workup for suspected or confirmed rhabdomyolysis., Assessment of skeletal muscle injury related to trauma, surgical procedures, or crush syndrome., Chest pain evaluation to help distinguish myocardial infarction from noncardiac causes., Monitoring the response to treatment and the evolution of muscle injury over time. |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- high-voltage electrical injury
- hemolysis
- intramuscular injections
- strenuous exercise
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.7 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Andersen PT, Moller-Petersen J, Henneberg EW, Egeblad K. Hypermyoglobinemia after successful arterial embolectomy. Surgery. 1987 Jul;102(1):25-31. PubMed 3296265
Gibler WB, Gibler CD, Weinshenker E, et al. Myoglobin as an early indicator of acute myocardial infarction. Ann Emerg Med. 1987 Aug;16(8):851-856. PubMed 3619163
Kasik JW, Leuschen MP, Bolam DL, Nellson RM. Rhabdomyolysis and myoglobinemia in neonates. Pediatrics. 1985 Aug;76(2):255-258. PubMed 4022700
Seguin J, Saussine M, Ferriere M, et al. Comparison of myoglobin and creatine kinase MB levels in the evaluation of myocardial injury after cardiac operations. J Thorac Cardiovasc Surg. 1988 Feb;95(2):294-297. PubMed 3257537