Deamidatsiyalangan gliadin antitanalari, IgA
Kod:16020|CPT:86258|LOINC:58709-7
| Kabi | Deamidatsiyalangan gliadin antitanalari, IgA |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment immunoanalizi (EIA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Avoid smoking for at least 30 minutes before the blood draw.
Qanday foydalanish
Deamidatsiyalangan gliadin antitanalari, IgA (antigliadin IgA; DGP IgA) seliak kasalligi va dermatit gerpetiformis tashxisini qo'llab-quvvatlaydi va avval aniqlangan kasallikni kuzatishda yordam beradi. U gumon qilingan glyutenga sezgir enteropatiyani dastlabki baholashda va vaqt davomida glyutensiz dietaga rioya etilishini obyektiv baholash uchun buyuriladi. To'qima transglutaminaza IgA va endomisiyal antitana testlari bilan birgalikda qo'llanganda, diagnostik samaradorlik, ayniqsa xavfi oshgan shaxslarda, yaxshilanadi.
Cheklovlar
Gliadin bug'doy, javdar, arpa va ayrim boshqa don ekinlarida mavjud bo'lgan glyutening tarkibiy qismidir. Genetik moyilligi bo'lgan shaxslarda u bilan ta'sirlanish shilliq qavatning immun javobini qo'zg'atib, ingichka ichakka shikast yetkazadi va seliak kasalligiga xos malabsorbsiyaga olib keladi. Kasallikka bog'liq antitanalarni, jumladan deamidatsiyalangan gliadin IgA ni aniqlashga qaratilgan serologik testlar diagnostik baholashni qo'llab-quvvatlaydi; biroq, mezon standart kichik ichak biopsiyasi orqali gistologik tasdiqlash bo'lib qoladi. Selektiv IgA yetishmovchiligi — seliak kasalligi bo'lgan bemorlar orasida ko'proq uchraydi — IgAga asoslangan tahlillarda yolg'on-manfiy natijalarga olib kelishi mumkin. Bu holatda jami zardob IgA ni o'lchash va parallel ravishda IgGga asoslangan tekshiruvlarni (masalan, deamidatsiyalangan gliadin IgG) o'tkazish tavsiya etiladi. Endomisiyal IgA yuqori darajada o'ziga xos, va to'qima transglutaminazaga qarshi antitanalar odatda gliadin serologiyasi bilan birga talqin qilinadi. Antitana titrlari qat'iy glyutensiz dietaga rioya qilinganda odatda pasayadi, bu esa serologiyani davolash va dietaga amal qilishni kuzatishda qo'llashga imkon beradi. Kasallik HLA-DQ2 va HLA-DQ8 bilan kuchli assotsiatsiyalangan, birinchi darajali qarindoshlarda xavf oshgan bo'lib, oilaviy skriningni ko'rib chiqishni qo'llab-quvvatlaydi.
| Referens oraliq | — |
|---|---|
| Ko'rsatmalar | Workup of suspected celiac disease with gastrointestinal complaints such as chronic diarrhea, recurrent vomiting, or abdominal pain., Assessment of poor growth or failure to thrive in children., Evaluation of iron-deficiency anemia without an identified cause., Skin findings compatible with dermatitis herpetiformis., Mucocutaneous conditions reported with gluten sensitivity, including atopic dermatitis, angular cheilitis, or recurrent aphthous ulcers., Neurologic or metabolic complications of malabsorption, for example peripheral neuropathy, osteopenia, hypocalcemic tetany, or a bleeding tendency., Reproductive concerns potentially linked to celiac disease, including amenorrhea, infertility, or erectile dysfunction., Testing individuals who have a first-degree relative with celiac disease., Follow-up of known celiac disease to monitor disease activity and adherence to a gluten-free diet., Targeted screening in associated conditions: type 1 diabetes mellitus, Hashimoto thyroiditis, systemic connective tissue diseases, alopecia totalis, and Down syndrome. |
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Qizil qopqoqli probirka, qo'shimchasiz (zardob) |
| Hajm | 1 mL (min 0.3 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
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Bhattacharyya R, Sharma N, Banerjee D. Design of peptide for immunodetection of IgA antigliadin antibody for the purpose of screening of celiac disease. Bioinformation. 2012;8(2):87-91.