Protein C antijeni
Kod:3010|CPT:85302|LOINC:27820-0
| Kabi | Protein C antijeni |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ferment immunoanalizi (EIA)
Kutilayotgan natija topshirish vaqti
3 kun
Maxsus tayyorlik
- If hematocrit is greater than 55%, adjust the sodium citrate volume according to coagulation collection guidelines.
- Avoid high‑fat foods for 24 hours before the blood draw.
- Refrain from strenuous exercise or significant emotional stress for at least 30 minutes before collection.
- Do not smoke during the 30 minutes prior to phlebotomy.
Qanday foydalanish
Protein C antijeni testi (Protein C yoki koagulyatsiya proteini C antijeni sifatida ham ataladi) Protein C yetishmovchiligini tasdiqlash va tavsiflash, shuningdek tug‘ma yetishmovchilikni orttirilgan kamayishdan ajratishga xizmat qiladi. U venoz tromboembolizm va erta yoshdagi arterial hodisalar bo‘yicha trombofiliya baholashlariga kiritiladi hamda homiladorlik davridagi trombotik asoratlar tekshiruvlarida qo‘llanadi. Tekshiruv, shuningdek, gomozygot yetishmovchilikka shubha uyg‘otuvchi og‘ir neonatal namoyon bo‘lishlarni baholashga hissa qo‘shadi. Ushbu analiz vitamin K antagonisti bilan davolash fonida tromboz sodir bo‘lganda va Protein C konsentratsiyasini pasaytirishi ma’lum bo‘lgan klinik holatlarda, jumladan vitamin K yetishmovchiligi, sintezi kamaygan jigar kasalligi, sepsis yoki og‘ir infeksiya va malignitetda buyurilishi mumkin.
Cheklovlar
Protein C antikoagulyatsiyaning markaziy regulyatori hisoblanadi. Trombin trombomodulin bilan bog‘langanda Protein C ni faollashtiradi, va faollashgan shakl, Protein S kofaktori ishtirokida, Va va VIIIa faktorlarini inaktivatsiya qiladi. Bu trombin hosil bo‘lishini susaytiradi va ikkilamchi tarzda fibrinolizni osonlashtiradi. Tug‘ma geterozygot yetishmovchilik venoz tromboz bilan bog‘liq bo‘lib, antijen qiymatlari past yoki past-me’yoriy oraliqda bo‘lishi mumkin. Gomozygot yoki qo‘shma geterozygot yetishmovchilik odatda neonatal davrda purpura fulminans va disseminirlangan intravaskulyar koagulyatsiya (DIC) bilan namoyon bo‘ladi. Protein C konsentratsiyasi vitamin K antagonisti terapiyasi vaqtida va koagulyatsiya faollashuvi davrlarida, jumladan o‘tkir trombotik hodisadan keyingi darhol intervalda pasayadi; bu holatlar tug‘ma yetishmovchilikni antijen yordamida aniqlash foydasini cheklaydi. Orttirilgan kamayishlar shuningdek vitamin K yetishmovchiligi, jigar tomonidan sintezning buzilishi, og‘ir infeksiya yoki sepsis va malignitetda kuzatiladi.
| O'lchov birligi | % | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Thrombophilia evaluation as part of a panel with antithrombin III, protein S, and related coagulation studies, Unprovoked venous thromboembolism—deep vein thrombosis or pulmonary embolism—especially at a young age, Early-onset arterial thrombosis, such as myocardial infarction or ischemic stroke, Suspected inherited protein C deficiency, including neonatal purpura fulminans, Pregnancy-associated thrombotic complications: preeclampsia or eclampsia, disseminated intravascular coagulation, fetal growth restriction, or recurrent pregnancy loss, Assessment during treatment with a vitamin K antagonist and when warfarin-induced skin necrosis is suspected, Clinical suspicion of vitamin K deficiency, Chronic liver disease with impaired synthetic capacity, Malignancy, severe infection, or sepsis accompanied by coagulopathy |
Natija og'ishlarining mumkin sabablari
Pasaygan daraja
- acute thrombosis
- warfarin
Namunangiz talablari
| Namunangiz | Plazma |
|---|---|
| Container | Och ko'k qopqoqli probirka (3,2% natriy sitrat) |
| Hajm | 1 mL |
| Saqlash tayyorlik | Muzlatilgan |
References
Долгов В.В., Меньшиков В.В. Клиническая лабораторная диагностика: национальное руководство. – Т. I. – М. : ГЭОТАР-Медиа, 2012. – 928 с.
Fauci, Braunwald, Kasper, Hauser, Longo, Jameson, Loscalzo Harrison’s principles of internal medicine, 17th edition, 2009.
Christiaans SC, Wagener BM, Esmon CT, Pittet JF. Protein C and acute inflammation: a clinical and biological perspective / Am J Physiol Lung Cell Mol Physiol. 2013 Oct 1;305(7):L455-66.
Bouwens EA1, Stavenuiter F, Mosnier LO. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway / J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53.