Tsistatin C
Kod:7026
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunoturbidimetriya
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not eat for 12 hours before the blood draw; water is allowed.
- Avoid vigorous exercise and emotional stress for 12 hours before collection.
Qanday foydalanish
Tsistatin C (CysC) testi buyrak funksiyasining boshlang‘ich darajasini aniqlash va vaqt davomida o‘zgarishlarni kuzatish uchun qon zardobidagi CysCdan glomerulyar filtratsiya tezligini baholash yo‘li bilan qo‘llaniladi. Kreatininga asoslangan eGFR noodatiy mushak massasi, pediatrik yosh yoki keksalik, yoki vegetarian parhez kabi ovqatlanish omillari tufayli ishonchsiz bo‘lishi mumkin bo‘lgan holatlarda ayniqsa foydali. Surunkali buyrak kasalligi sharoitida tsistatin C yurak-qon tomir xavfini tabaqalashtirishga ham hissa qo‘shishi mumkin.
Cheklovlar
Tsistatin C yadroli hujayralar tomonidan nisbatan doimiy tezlikda ishlab chiqariladi. U glomerulyar filtrdan erkin o‘tadi va keyin proksimal naycha hujayralari tomonidan deyarli to‘liq reabsorbsiyalanib parchalanadi hamda qon aylanishiga qaytmaydi; shuning uchun zardob darajalari asosan glomerulyar filtratsiyani aks ettiradi. GFR kamayganda, zardobdagi tsistatin C ortadi, va tasdiqlangan tenglamalar tsistatin C o‘lchovlaridan eGFRni hisoblashga imkon beradi. Buyrak baholashidan tashqari, CysC hujayradan tashqari matritsaning almashinuvida ishtirok etadi va ateroskleroz hamda miokard remodellasiyasi bilan bog‘langan; uni yurak-qon tomir xavfini baholashda qo‘llash bo‘yicha tadqiqotlar davom etmoqda. Normal homiladorlikda tsistatin Cdan hisoblangan eGFR kamroq aniqlikka ega bo‘lishi mumkin, va qalqonsimon bez disfunktsiyasi GFRdan mustaqil ravishda zardob tsistatin C darajasini o‘zgartirishi mumkin.
| O'lchov birligi | mg/L | ||||
|---|---|---|---|---|---|
| Referens oraliq |
| ||||
| Ko'rsatmalar | Evaluate and track renal impairment when creatinine‑derived eGFR is unreliable (unusual body habitus or muscle mass, vegetarian diet, children or older adults)., Identify early kidney disease in patients with normal or borderline creatinine values., Support cardiovascular risk stratification, especially in individuals with chronic kidney disease. |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- glucocorticoids
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
References
McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Elsevier; 2016:170.
Fischbach F, Dunning MB III. A Manual of Laboratory and Diagnostic Tests. 9th ed. Wolters Kluwer Health; 2015:367.
Velkov VV. Cystatin C: indicator of glomerular filtration rate and a marker of severity of cardiovascular events. Laboratory Medicine. 2011;11:57-64.