Qondagi urea (karbamid) azoti (BUN)
Kod:8024|CPT:84520|LOINC:3094-0
| Kabi | Urea (karbamid) azoti (BUN) |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Ureaza usuli
- Kinetik ultrabinafsha (UV) usul
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Do not eat for 12 hours before the blood draw.
- For at least 30 minutes before collection, avoid strenuous activity, minimize stress, and do not smoke.
Qanday foydalanish
Qondagi urea (karbamid) azoti (BUN)—qondagi urea yoki karbamid nomlari bilan ham yuritiladi—kreatinin bilan birga buyrak funksiyasi va azot balansini baholash uchun qo‘llaniladi. U o‘tkir buyrak shikastlanishi va surunkali buyrak kasalligini tashxislash va monitoring qilishni qo‘llab-quvvatlaydi, prerenal azotemiyani intrarenal buyrak kasalligi va postrenal obstruksiyadan farqlashga yordam beradi hamda gemodializ yoki boshqa buyrak o‘rnini bosuvchi terapiyaning samaradorligini kuzatishda qo‘llanadi. BUNning ko‘tarilishi buyrak perfuziyasining pasayishi (masalan, shok), siydik yo‘llari obstruksiyasi, katabolik holatlar, degidratsiya, me’da-ichakdan qon ketishi, yuqori oqsil iste’moli yoki dori ta’sirlarini aks ettirishi mumkin; kreatininga nisbatan nomutanosib oshish prerenal etiologiyani qo‘llab-quvvatlaydi. Past BUN ortiqcha gidratsiya, normal homiladorlik, oqsil iste’molining kamayishi yoki jigarda urea sintezining buzilishi bilan kuzatilishi mumkin.
Cheklovlar
Urea jigarida oqsil katabolizmi chog‘ida ajralib chiqadigan ammiakdan sintezlanadi, qon aylanishiga tushadi va buyraklarga yetkaziladi; u yerda glomerulda erkin filtrlanadi va siydik bilan chiqariladi. Shunga muvofiq, qondagi urea azoti konsentratsiyasi jigar tomonidan ishlab chiqarish va buyrak orqali chiqarib tashlash o‘rtasidagi muvozanatni aks ettiradi. Ratsiondagi oqsil miqdori, katabolizm darajasi, gidratsiya holati va buyrak funksiyasi BUN darajasiga ta’sir qiladi. Jigarning ureani ishlab chiqarish qobiliyatining kamayishi BUNni pasaytiradi va giperammonemiya hamda gepatik ensefalopatiya bilan kechishi mumkin. Uremiyani baholash eng informativ bo‘ladi, agar qondagi urea azoti kreatinin bilan birga talqin qilinsa; prerenal va postrenal azotemiyada BUN ko‘pincha kreatininga nisbatan ko‘proq oshadi. Progrediyent surunkali buyrak kasalligida yaqqol azotemiya paydo bo‘lishidan oldin odatda sezilarli nefron yo‘qotilishi yuz beradi.
| O'lchov birligi | mg/dL | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Referens oraliq |
| |||||||||||||||
| Ko'rsatmalar | Baseline renal assessment performed together with creatinine, Diagnosis and longitudinal follow-up of acute kidney injury and chronic kidney disease, Workup of prerenal azotemia due to reduced renal perfusion, Assessment for postrenal urinary tract obstruction, Monitoring the effectiveness of hemodialysis or other renal replacement therapy, Pre-treatment evaluation before initiating potentially nephrotoxic medications, Admission laboratory testing in the setting of acute illness, Inpatient surveillance of kidney function, Signs or symptoms of renal impairment: edema (facial, peripheral, ascites), oliguria or anuria, dysuria or nocturia, proteinuria or hematuria, flank pain, Hypertension or comorbid conditions associated with renal dysfunction (diabetes mellitus, congestive heart failure, recent myocardial infarction) |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- aspirin
- cephalosporins
- cisplatin
- high protein intake
- older age
- tetracyclines
- thiazide diuretics
Pasaygan daraja
- early childhood
- pregnancy
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 1 mL (min 0.7 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |