Inhibin B
Kod:9015|CPT:83520|LOINC:34319-4
| Kabi | Inhibin B |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- ANSHLITE ferment immunoanalizi
- Ferment bilan bog'langan immunosorbent analiz (ELISA)
Kutilayotgan natija topshirish vaqti
1–2 kun
Maxsus tayyorlik
- Avoid high-dose biotin (vitamin B7/B8, vitamin H, coenzyme R) for at least 72 hours before the blood draw.
- Infants younger than 1 year: hold feeds for 30–40 minutes prior to collection.
- Adults and children ≥1 year: do not eat for 2–3 hours before collection; water is allowed.
- If clinically appropriate, withhold estrogens and androgens for 48 hours before collection.
- For cycle-based evaluation, collect the specimen on menstrual cycle day 3–4.
- Avoid physical or emotional stress for 30 minutes before phlebotomy.
- Do not smoke for 3 hours before collection.
Qanday foydalanish
Inhibin B testi (follikulni stimullovchi gormon sekretsiyasi ingibitori sifatida ham ma'lum) ayollarda antral follikul funksiyasini baholash va erkaklarda Sertoli hujayralari faolligi hamda sperma ishlab chiqarilishini baholash uchun qo'llaniladi. Bepushtlikni aniqlashda u FSH bilan birga talqin qilinadi, tuxumdon zaxirasini (ovarial rezerv) taxmin qilish va erkak omiliga bog'liq bepushtlikni tavsiflash uchun ishlatiladi. Shuningdek, inhibin B ni overekspressiya qiladigan granuloza hujayra o'smalari va mutsinoz epitelial tuxumdon o'smalarini tashxislash va kuzatishda yordam beradi. Qo'shimcha qo'llanilish sohalariga pubertatning g'ayritabiiy vaqtlanishini baholash, jinsiy rivojlanish buzilishlarini aniqlash va o'g'il bolalarda kriptorxizm va anorxiyani farqlash kiradi.
Cheklovlar
Inhibin B α va β subbirliklardan tashkil topgan, ular disulfid bog'lar bilan birikkan transformatsiyalovchi o'sish omili-β (TGF-β) oilasiga mansub gormondir. U gipofiz FSHiga manfiy teskari aloqa orqali ta'sir ko'rsatadi va gonadalar ichida lokal parakrin effektlarga ega. Sekretsiya gonadotropinlarni chiqaruvchi gormon (GnRH) ta'sirida kamayadi, androgenlar, FSH va insulinga o'xshash o'sish omili-1 (IGF-1) bilan ortadi. Ayollarda asosiy manba antral follikullardir. Konsentratsiya follikulyar fazaning boshida ko'tariladi, o'rta follikulyar bosqichda cho'qqiga chiqadi, lyuteal fazada past bo'lib qoladi va ovulyatsiya yaqinida LH cho'qqisidan taxminan ikki kun o'tib qisqa muddatli ko'tarilishni namoyon etadi. Yosh o'tishi bilan follikul soni kamaygani sari, follikulyar fazadagi inhibin B estradiol yoki inhibin A ga nisbatan ertaroq pasayadi; postmenopauza davrida qiymatlar juda past yoki aniqlanmaydi, va bu sharoitda keskin yuqori ko'rsatkichlar granuloza hujayrali yoki mutsinoz tuxumdon karsinomasini ko'rsatishi mumkin. Inhibin B ni CA 125 va tasvirlash usullari bilan birgalikda qo'llash o'smalarni aniqlashni yaxshilaydi va davolash monitoringini qo'llab-quvvatlaydi. Tuxumdon zaxirasini baholash uchun natijalar odatda siklning 3-kunida olingan FSH va anti-Myuller gormoni bilan birga talqin qilinadi. Erkaklarda inhibin B FSHning muhim regulyatoridir. Kattalarda darajalar nisbatan barqaror, moyak hajmi va sperma ishlab chiqarilishi bilan bog'liq va oligozoospermiya, azoospermiya hamda spermatogenez buzilishida kamayadi. O'g'il bolalarda aniqlanadigan konsentratsiyalar moyak to'qimasining mavjudligi va funksiyasini ko'rsatadi hamda anorxiyani kriptorxizmdan farqlashga yordam beradi. Menstrual sikl davomida konsentratsiyalar o'zgarib turishi sababli, premenopauzal ayollarda talqin qilish murakkabroq; natijalar klinik topilmalar va boshqa diagnostik tadqiqotlar bilan integratsiyalangan holda baholanishi zarur va malignitet uchun yoki unga qarshi qat'iy dalil hisoblanmaydi.
| O'lchov birligi | pg/mL |
|---|---|
| Referens oraliq | — |
| Ko'rsatmalar | Clinical concern for granulosa cell tumor or mucinous epithelial ovarian carcinoma, Baseline measurement and serial monitoring during and after therapy for ovarian neoplasms, Assessment of abnormal pubertal timing, including precocious or delayed puberty, Suspected impaired spermatogenesis in males, Infertility evaluation in women and men, Evaluation of gonadal developmental anomalies in boys, Preprocedural assessment for assisted reproductive technology, Workup of disorders of sex development or ambiguous genitalia in children, with adjunctive sex hormone testing and imaging when indicated |
Natija og'ishlarining mumkin sabablari
Pasaygan daraja
- alcohol abuse
- smoking
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.6 mL (min 0.3 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Fisher D.A. The Quest Diagnostics Manual: Endocrinology Test Selection and Interpretation. 4th ed. San Juan Capistrano, CA: Quest Diagnostics Nichols Institute; 2007:369 pp.
Nazarenko G., Kishkun A. Clinical Evaluation of Laboratory Test Results. Moscow: Meditsina; 2000:427-429.