O‘sish gormoni (somatotropin)
Kod:9055|CPT:83003|LOINC:2963-7
| Kabi | O‘sish gormoni, qon zardobi |
|---|
Tahlil ma'lumotlari
Tadqiqot usuli
- Immunokimyoluminometrik analiz (ICMA)
- Elektrokimyoluminessent immunoanaliz (ECLIA)
Kutilayotgan natija topshirish vaqti
1 kun
Maxsus tayyorlik
- Infants younger than 1 year: do not feed for 30–40 minutes before the blood draw.
- Children 1–5 years: fast for 2–3 hours before collection.
- Patients aged 5 years and older, including adults: fast for 10–12 hours before collection; water is allowed.
- Avoid high-fat foods for 24 hours before the test.
- With clinician approval, hold medications for 24 hours prior to collection.
- Avoid strenuous physical activity and significant emotional stress for 24 hours before collection.
- Do not smoke during the 3 hours preceding the blood draw.
- Stop biotin supplements for at least 72 hours before collection due to potential assay interference.
Qanday foydalanish
O‘sish gormoni testi (inson o‘sish gormoni, hGH) GH yetishmovchiligi yoki ortiqligi gumon qilinganda gipotalamo-gipofizar o‘q funksiyasini baholashga yordam beradi. U bolalarda past bo‘y va bo‘y o‘sish tezligining sekinlashuvini baholashga, kattalarda akromegaliya va bolalarda gigantizmni diagnostik tekshiruviga xizmat qiladi. GH yetishmovchiligi gumon qilinganda insulin, arginin, klonidin yoki glyukagon kabi vositalardan foydalanilgan dinamik GH rag‘batlantirish sinovlari qo‘llanadi; GH ortiqligi gumon qilinganda og‘iz orqali glyukoza yuklamasi bilan bostirish sinovi qo‘llanadi. IGF-1 vaqt bo‘yicha integrallashgan GH sekretsiyasining nisbatan barqaror ko‘rsatkichi hisoblanadi. Ushbu tahlil terapevtik javobni kuzatish hamda GH bilan bog‘liq kasalliklar qaytalanishini uzoq muddatli monitoring qilishni, shu jumladan kranial nurlanish olgan va gipofiz disfunktsiyasi xavfi mavjud shaxslarda, qo‘llab-quvvatlaydi.
Cheklovlar
O‘sish gormoni sekretsiyasi epizodik bo‘lib, kechasi ortadi; shuning uchun alohida olingan och qoringa GH konsentratsiyasi diagnostik jihatdan cheklangan foydaga ega. Dinamik protokollar afzal: farmakologik rag‘batlantirish sinovlari GH yetishmovchiligini aniqlashga yordam beradi, GH ortiqligi gumon qilinganda esa bostirilishni baholash uchun og‘iz orqali glyukoza yuklamasi qo‘llanadi. IGF-1 o‘lchovi vaqt bo‘yicha o‘rtacha GH faolligini aks ettirib, ushbu protseduralarni to‘ldiradi. GH bolalikda normal chiziqli o‘sishni ta’minlaydi va kattalarda suyak mineralizatsiyasi, skelet mushaklari massasi hamda lipid almashinuviga hissa qo‘shadi. Uzoq davom etuvchi GH ortiqligi, ko‘pincha gipofiz adenomasidan kelib chiqib, bolalarda gigantizmni, kattalarda akromegaliyani keltirib chiqaradi va 2-tur qandli diabet, gipertenziya, kardiometabolik xavfning oshishi, artropatiya va umr davomiyligining qisqarishi kabi asoratlar bilan bog‘liq. Kattalarda GH yetishmovchiligi suyak zichligining pasayishi va tana tarkibining o‘zgarishi bilan bog‘liq bo‘lishi mumkin; biroq bu xususiyatlarning haqiqiy GH yetishmovchiligi bilan bog‘liq sababi kam uchraydi.
| O'lchov birligi | ng/mL | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Referens oraliq |
| ||||||||||||
| Ko'rsatmalar | Child with proportionate short stature and reduced height velocity, Workup of short stature after hypothyroidism has been excluded, Radiographic evidence of delayed bone age, Concern for hypopituitarism, Adult GH deficiency evaluation in the setting of low bone mineral density, dyslipidemia, diminished exercise tolerance, or fatigue, Clinical signs suggestive of acromegaly in adults or gigantism in children, Suspected GH-secreting pituitary adenoma; assessment of treatment response in acromegaly or gigantism, History of cranial irradiation with impaired growth or risk for pituitary dysfunction, Ongoing surveillance to identify recurrence of GH excess or deficiency |
Natija og'ishlarining mumkin sabablari
Oshgan daraja
- amphetamines
- arginine
- dopamine
- estrogens
- glucagon
- histamine
- insulin
- levodopa
- methyldopa
- nicotinic acid
Pasaygan daraja
- biotin
- corticosteroids
- phenothiazines
Namunangiz talablari
| Namunangiz | Zardob |
|---|---|
| Container | Oltin/yo'lbars qopqoqli probirka (SST, gel ajratgich) |
| Hajm | 0.8 mL (min 0.2 mL) |
| Saqlash tayyorlik | Xona harorati, Sovutilgan, Muzlatilgan |
References
Donaldson DL, Pan F, Hollowell JG, et al. Reliability of stimulated and spontaneous growth hormone (GH) levels for identifying the child with low GH secretion. J Clin Endocrinol Metab. 1991 Mar;72(3):647-652. PubMed 1671784.
Ilondo MM, Vanderschueren-Lodeweyckx M, De Meyts P, Eggermont E. Serum growth hormone levels measured by radioimmunoassay and radioreceptor assay: A useful diagnostic tool in children with growth disorders? J Clin Endocrinol Metab. 1990 May;70(5):1445-1451. PubMed 2186059.
Rose SR, Ross JL, Uriarte M, Barnes KM, Cassorla FG, Cutler GB Jr. The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med. 1988 Jul 28;319(4):201-207. PubMed 3393172.
Rosenfield RG. Disorders of growth hormone and insulin-like growth factor secretion and action. In: Sperling MA, ed. Pediatric Endocrinology. Philadelphia, PA: WB Saunders Co; 1996:117-169.
Wass JAH, Besser GM. Tests of pituitary function. In: DeGroot LJ, Besser GM, Burger HG, et al, eds. Endocrinology. 3rd ed. Philadelphia, PA: WB Saunders Co; 1994:487-496.